Cerhan Jane H, Caine Chip, Anderson S Keith, Johnson Derek R, Lachance Daniel H, Yan Elizabeth, Brown Paul D
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN.
Intermountain Medical Center, Neurosciences Institute, Intermountain Medical Center, Murray, Utah.
Neurooncol Pract. 2019 Jan;6(1):71-77. doi: 10.1093/nop/npy013. Epub 2018 May 21.
Cognitive function is an important outcome measure in many brain tumor clinical trials, and investigators are interested in employing the most efficient methods of cognitive assessment for this purpose. Computerized testing can be appealing because of the perceived ease of use and electronic data generated. Traditional tests may have the advantage of accumulated validity evidence and comparability across historic trials.
We evaluated feasibility of a Cogstate battery in 39 patients with high-grade glioma, and compared it with a commonly used paper-and-pencil battery.
Both batteries were well tolerated and rated equally likeable. Correlations between the batteries were low to low-moderate. More patients showed impairment at baseline and decline across trials on traditional tests.
Both batteries were well tolerated, but the most complicated tasks (from both batteries) could not be completed by all subjects. Preliminary validity evidence for the Cogstate tasks was mixed, but a larger sample is needed.
认知功能是许多脑肿瘤临床试验中的一项重要结局指标，研究人员有兴趣为此采用最有效的认知评估方法。计算机化测试因其使用便捷以及能生成电子数据而颇具吸引力。传统测试可能具有积累的效度证据以及在历史试验中的可比性优势。
我们评估了39例高级别胶质瘤患者使用Cogstate测试组套的可行性，并将其与常用的纸笔测试组套进行比较。
两种测试组套的耐受性均良好，且评分相当。两组测试组套之间的相关性为低到中度。更多患者在基线时表现出损伤，并且在传统测试的各次试验中出现下降。
两种测试组套的耐受性均良好，但所有受试者无法完成（两组测试组套中）最复杂的任务。Cogstate测试任务的初步效度证据不一，但需要更大的样本量。
