Stiner Rachel K, Clarke Jennifer L, Sinha Nikita, Chan Jessica, Letourneau Joseph M, Niemasik Erin E, Rabbitt Jane E, Chang Susan M, Butowski Nicholas A, Prados Michael D, Rosen Mitchell P
Department of Neurological Surgery, University of California, San Francisco, USA.
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, USA.
Neurooncol Pract. 2019 May;6(3):218-225. doi: 10.1093/nop/npy036. Epub 2018 Sep 26.
No studies have examined the fertility priorities of women undergoing treatment for their glioma. Glioma patients frequently undergo chemotherapy as part of their treatment; however, it is unknown whether patients truly are aware of its possible effects on their fertility. Our objective was to assess the fertility priorities of glioma patients and ascertain whether female glioma patients are being effectively counseled on the effects of chemotherapy on their fertility prior to beginning treatment.
The sample was composed of female patients from the Neuro-oncology clinic of the University of California, San Francisco. Participants completed a cross-sectional survey between October 2010 and December 2013 exploring their attitudes toward fertility and their experience with fertility counseling prior to chemotherapy initiation.
Seventy-two women completed the survey. Analysis of the survey results showed that 30% of women receiving chemotherapy reported having a discussion regarding fertility preservation prior to beginning treatment. Of those who reported having this discussion, 80% were aware that chemotherapy could negatively affect their fertility. Many women reported that while fertility preservation was not important to them at the time of diagnosis, it was a priority for them at the time of survey completion. Although interest in having children tended to decrease after cancer treatment, the majority of respondents reported wanting a child after treatment.
The data obtained in this study suggest a lack of understanding of reproductive priorities, which may be addressed with a more comprehensive fertility discussion prior to beginning treatment.
尚无研究探讨接受神经胶质瘤治疗的女性的生育优先事项。神经胶质瘤患者经常接受化疗作为其治疗的一部分；然而，患者是否真正意识到化疗对其生育能力可能产生的影响尚不清楚。我们的目的是评估神经胶质瘤患者的生育优先事项，并确定女性神经胶质瘤患者在开始治疗前是否就化疗对其生育能力的影响得到了有效的咨询。
样本由来自加利福尼亚大学旧金山分校神经肿瘤诊所的女性患者组成。参与者在2010年10月至2013年12月期间完成了一项横断面调查，探讨她们对生育的态度以及在开始化疗前接受生育咨询的经历。
72名女性完成了调查。对调查结果的分析表明，30%接受化疗的女性报告在开始治疗前曾讨论过生育力保存问题。在那些报告进行过此类讨论的女性中，80%意识到化疗可能会对其生育能力产生负面影响。许多女性报告说，虽然生育力保存在诊断时对她们并不重要，但在调查完成时却是她们的优先事项。尽管癌症治疗后生育子女的意愿往往会降低，但大多数受访者表示希望治疗后生育子女。
本研究获得的数据表明对生殖优先事项缺乏了解，这可能通过在开始治疗前进行更全面的生育讨论来解决。
