Koekkoek Johan A F, Dirven Linda, Reijneveld Jaap C, Postma Tjeerd J, Grant Robin, Pace Andrea, Oberndorfer Stefan, Heimans Jan J, Taphoorn Martin J B
Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands (J.A.F.K., L.D., J.C.R., T.J.P., J.J.H., M.J.B.T.); Department of Neurology, Medical Center Haaglanden, The Hague, The Netherlands (J.A.F.K., M.J.B.T.); Edinburgh Centre for Neuro-Oncology, Western General Hospital, Edinburgh, Scotland (R.G.); Neuro-Oncology Unit, Regina Elena Cancer Institute, Rome, Italy (A.P.); Department of Neurology, Landesklinikum St. Pölten, Sankt Pölten, Austria (S.O.).
Neurooncol Pract. 2014 Sep;1(3):134-140. doi: 10.1093/nop/npu018.
Epileptic seizures are common in patients with primary or secondary malignant brain tumor. However, current knowledge on the occurrence of seizures during the end of life (EOL) phase of brain tumor patients is limited. Because symptom management with preservation of quality of life is of major importance for patients with a malignant brain tumor, particularly in the EOL, it is necessary to gain a deeper understanding of seizures and their management during this phase. We performed a systematic review of literature related to epilepsy in the EOL phase of brain tumor patients, based on the electronic resources PubMed, Embase, and Cinahl. The search yielded 442 unique records, of which 11 articles were eligible for further analysis after applying predefined inclusion criteria. Seizures occur relatively frequently in the EOL phase, particularly in patients with high-grade glioma. However, seizure management is often hampered by swallowing difficulties and impaired consciousness. Treatment decisions are largely dependent on expert opinion because a standardized approach for treating seizures in the terminal stage of brain tumor patients is still lacking.
癫痫发作在原发性或继发性恶性脑肿瘤患者中很常见。然而，目前关于脑肿瘤患者生命终末期（EOL）癫痫发作情况的了解有限。由于症状管理以及生活质量的维持对于恶性脑肿瘤患者至关重要，尤其是在生命终末期，因此有必要更深入地了解这一阶段的癫痫发作及其管理。我们基于电子资源PubMed、Embase和Cinahl对与脑肿瘤患者生命终末期癫痫相关的文献进行了系统综述。检索共得到442条独立记录，应用预定义的纳入标准后，其中11篇文章符合进一步分析的条件。癫痫发作在生命终末期相对频繁发生，尤其是在高级别胶质瘤患者中。然而，吞咽困难和意识障碍常常阻碍癫痫发作的管理。治疗决策很大程度上依赖专家意见，因为仍缺乏针对脑肿瘤患者终末期癫痫发作的标准化治疗方法。
