Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China.
Neurogastroenterol Motil. 2019 Oct;31(10):e13681. doi: 10.1111/nmo.13681. Epub 2019 Aug 6.
We previously published that altered expression of gastric TRPV1, BDNF, and peripheral cytokines was present in patients with functional dyspepsia. We herein examine whether genetic predisposition in altered biomarkers influences dyspeptic, sleep, and mood symptoms in patients with FD without previous infection.
Consecutive adult FD patients (Rome III) with no recent history of gastroenteritis and asymptomatic age- and sex-matched healthy controls were recruited for upper endoscopy. Subjects with GERD and IBS as predominant symptoms, diabetes mellitus, current or previous H pylori infection, psychiatric illness, and recent use of NSAID or PPI were excluded. The genetic associations with dyspeptic symptoms, sleep quality, and mood symptoms were evaluated. Genetic polymorphisms in TRPV1, TGFB1, TNF, COMT, BDNF, IL6, IL8, IL10, and IL12 were analyzed.
Twenty-nine male FD patients and 104 female FD patients were age matched (±3 years) with 81 healthy subjects. All had postprandial distress syndrome (PDS) as predominant subtype (PDS: 130, EPS: 3). SNPs in TGFB1 showed significant associations in dyspeptic patients after age and sex adjustment [for RS4803455: in the codominant model (C/A, OR = 0.34 (0.18-0.65), P = .004); in the dominant model (genotype C/C vs C/A-A/A, OR = 0.42 (0.23-0.77), P = .004); and in the overdominant model (genotype C/C-A/A vs C/A, OR = 0.38 (0.21-0.70), P < .001)] [for RS1800469: in dominant model (genotype A/A vs A/G-G/G, OR = 0.52 (0.27-0.99), P = .043)]. A allele in RS4803455 was associated with higher HADS depression score (P = .05) and epigastric burning sensation(P = .01).
Our data showed that dyspeptic patients predispose genetic difference in TGFB1 which may influence the severity of dyspepsia.
我们之前发表过，功能性消化不良患者的胃 TRPV1、BDNF 和外周细胞因子表达发生改变。本研究旨在探讨功能性消化不良患者中，改变的生物标志物的遗传易感性是否会影响无近期感染史的患者的消化不良、睡眠和情绪症状。
连续招募了符合罗马 III 标准的无近期肠胃炎史的成年功能性消化不良患者（FD）和年龄、性别匹配的无症状健康对照者进行上内窥镜检查。排除 GERD 和 IBS 为主诉、糖尿病、现症或既往 Hp 感染、精神疾病以及近期使用 NSAID 或 PPI 的患者。评估遗传与消化不良症状、睡眠质量和情绪症状的相关性。分析 TRPV1、TGFB1、TNF、COMT、BDNF、IL6、IL8、IL10 和 IL12 的基因多态性。
29 名男性 FD 患者和 104 名女性 FD 患者与 81 名健康对照者的年龄相匹配（±3 岁），且所有患者均为餐后不适综合征（PDS）为主型（PDS：130 例，EPS：3 例）。TGFB1 的 SNP 在年龄和性别调整后，在消化不良患者中存在显著相关性[对于 RS4803455：在共显性模型（C/A，OR=0.34（0.18-0.65），P=0.004）；在显性模型（基因型 C/C 比 C/A-A/A，OR=0.42（0.23-0.77），P=0.004）；和在超显性模型（基因型 C/C-A/A 比 C/A，OR=0.38（0.21-0.70），P<0.001）][对于 RS1800469：在显性模型（基因型 A/A 比 A/G-G/G，OR=0.52（0.27-0.99），P=0.043）]。RS4803455 的 A 等位基因与更高的 HADS 抑郁评分（P=0.05）和上腹痛（P=0.01）相关。
本研究数据表明，消化不良患者易发生 TGFB1 基因差异，这可能会影响消化不良的严重程度。
