TRPV1 315C 纯合子影响功能性消化不良的易感性。

Homozygous TRPV1 315C influences the susceptibility to functional dyspepsia.

机构信息

Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

出版信息

J Clin Gastroenterol. 2010 Jan;44(1):e1-7. doi: 10.1097/MCG.0b013e3181b5745e.

DOI:10.1097/MCG.0b013e3181b5745e

PMID:19770677

Abstract

OBJECTIVES

Capsaicin/vanilloid (transient receptor potential vanilloid 1, (TRPV1) receptor has been shown to be expressed in gastrointestinal tract and play a role as a member of sensory ion channel superfamily. The G315C polymorphism affects the TRPV1 gene and alters its protein level. We aimed to investigate the effect of TRPV1 G315C polymorphism on functional dyspepsia (FD) in a Japanese population.

METHODS

TRPV1 G315C polymorphism was genotyped in 98 subjects with no upper abdominal symptoms and 109 patients with FD. Severity of 7 upper gastrointestinal symptoms was assessed during cold water, and cold carbonated water drinking for randomly selected 20 healthy subjects.

RESULTS

We found a significant inverse association between TRPV1 315CC genotype and FD [CC vs. others; odds ratio (OR)=0.40, 95% confidence interval (CI)=0.38-0.82]. We also found that the same genotype held a lower risk of both epigastric pain syndrome (OR=0.25, 95% CI=0.09-0.73), postprandial syndrome (OR=0.27, 95% CI=0.07-0.96) according to Rome III, and Helicobacter pylori positive FD (OR=0.28, 95% CI=0.10-0.79). The evolution of symptom severity scale of 7 total symptoms (P=0.004), and heavy feeling in stomach (P=0.02) during cold carbonated water drinking were significantly lower among 315CC genotypes compared with others.

CONCLUSIONS

Homozygous TRPV1 315C influences the susceptibility to FD through altering the upper gastrointestinal sensation.

摘要

目的

辣椒素/香草素（瞬时受体电位香草素 1，（TRPV1）受体已被证明在胃肠道中表达，并作为感觉离子通道超家族的成员发挥作用。G315C 多态性影响 TRPV1 基因并改变其蛋白水平。我们旨在研究 TRPV1 G315C 多态性对日本人群功能性消化不良（FD）的影响。

方法

对 98 例无上腹部症状的受试者和 109 例 FD 患者进行 TRPV1 G315C 多态性基因分型。随机选择 20 例健康受试者进行冷水和冷碳酸水饮用，评估 7 种上消化道症状的严重程度。

结果

我们发现 TRPV1 315CC 基因型与 FD 之间存在显著的负相关[CC 与其他基因型；比值比（OR）=0.40，95%置信区间（CI）=0.38-0.82]。我们还发现，同一基因型患上腹痛综合征（OR=0.25，95%CI=0.09-0.73）和餐后综合征（OR=0.27，95%CI=0.07-0.96）的风险较低，符合罗马 III 标准，以及 Hp 阳性 FD（OR=0.28，95%CI=0.10-0.79）。7 种总症状严重程度评分的变化（P=0.004），以及冷碳酸水饮用时胃部沉重感（P=0.02）在 315CC 基因型中明显低于其他基因型。