Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis , University of Science and Technology of China, Chinese Academy of Sciences , Hefei , 230026 , People's Republic of China.
State Key Laboratory of Applied Organic Chemistry , Lanzhou University , Lanzhou , 730000 , People's Republic of China.
Org Lett. 2019 Aug 16;21(16):6333-6336. doi: 10.1021/acs.orglett.9b02230. Epub 2019 Aug 6.
A novel and atom-economic palladium-catalyzed isomerization-hydrocarbonylative cyclization reaction of 1,5-dienes to 2-alkylidenecyclopentanones has been developed, which provides a rapid and straightforward approach to 2-alkylidenecyclopentanones with high stereoselectivity. The reaction was found to proceed via alkene isomerization and selective hydrocarbonylative cyclization to generate 2-alkylidenecyclopentanones with high selectivity.
一种新型的原子经济性钯催化 1,5-二烯异构化-氢甲酰化环化反应已经被开发出来，该反应为高立体选择性的 2-亚甲基环戊酮提供了一种快速而直接的方法。该反应通过烯烃异构化和选择性氢甲酰化环化进行，生成具有高选择性的 2-亚甲基环戊酮。
