Asserese Ketema Alemayehu, Huang Hanmin
Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, People's Republic of China.
Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, University of Science and Technology of China, Hefei 230026, People's Republic of China.
Org Lett. 2023 Feb 24;25(7):1109-1113. doi: 10.1021/acs.orglett.3c00019. Epub 2023 Feb 10.
A novel palladium-catalyzed cascade hydrocarbonylation of the alkene moiety followed by intramolecular spirolactonization of 2-vinylaryl hydroxyalkyl ketones has been developed, which offers efficient and expedited access to furnishing oxaspirolactones in high yields with high chemoselectivities. This new method is compatible with an array of functional groups and proceeds under mild reaction conditions with commercially available catalyst components.
已开发出一种新型钯催化的烯烃部分的级联氢甲酰化反应，随后是2-乙烯基芳基羟烷基酮的分子内螺内酯化反应，该反应能高效、快速地以高收率和高化学选择性制备氧杂螺内酯。这种新方法与一系列官能团兼容，并且在温和的反应条件下使用市售催化剂组分进行反应。
