5-氟尿嘧啶与短小棒状杆菌治疗晚期结直肠癌的试验。
A trial of 5-fluorouracil and Corynebacterium parvum in advanced colorectal carcinoma.
作者信息
Gough I R, Clunie G J, Bolton P M, Dury M, Burnett W
出版信息
Dis Colon Rectum. 1979 May-Jun;22(4):223-7. doi: 10.1007/BF02586879.
This study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum IgM. Serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, T-lymphocyte counts, B-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. In 33 patients chosen at random to receive either 5-FU alone or 5-FU in combination with intramuscularly administered C. parvum, there was no evidence of objective response or influence on survival. Intramuscularly administered C. parvum, in the dose and schedule used, produced no evident immunologic or therapeutic effect.
本研究证实，患有晚期结直肠癌的患者对迟发型超敏皮肤试验的反应性受损，且血清IgM水平升高。对接受单纯化疗或化疗免疫疗法的患者进行的迟发型超敏皮肤试验、总淋巴细胞计数、T淋巴细胞计数、B淋巴细胞计数及血清免疫球蛋白水平的系列观察，未能揭示任何一致的反应模式。在随机选择接受单纯5-氟尿嘧啶或5-氟尿嘧啶联合肌肉注射微小隐孢子虫治疗的33例患者中，没有客观反应或对生存有影响的证据。按所使用的剂量和疗程肌肉注射微小隐孢子虫，未产生明显的免疫或治疗效果。
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