反复注射短小棒状杆菌和卡介苗治疗对免疫参数的影响：黑色素瘤患者的每周序贯研究。I. 非特异性（自然杀伤细胞、杀伤细胞和T细胞）淋巴细胞毒性、外周血细胞计数及迟发型超敏反应的变化
Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions.
作者信息
Thatcher N, Swindell R, Crowther D
出版信息
Clin Exp Immunol. 1979 May;36(2):227-36.
Abstract
Increased lymphocyte cytotoxicity, particularly of 'killer' K cell type was recorded with repeated immunizations of either C. parvum or BCG. A 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. No marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. Expression of cytotoxicity results as percentage 51Cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymphocyte curves) are described. A 3 week immunization schedule is suggested where BCG and C. parvum are used as immunotherapeutic agents, in the doses quoted.
摘要
用微小隐孢子虫或卡介苗重复免疫时，观察到淋巴细胞细胞毒性增加，尤其是“杀伤性”K细胞类型。两次免疫之间间隔3周能够维持细胞毒性的增加。未观察到“回忆”性皮肤超敏反应或外周血细胞计数有明显改变。描述了以51Cr释放百分比、裂解单位/毫升和细胞毒性能力（对细胞毒性淋巴细胞曲线进行对数转化后）表示的细胞毒性结果。建议采用3周免疫方案，将卡介苗和微小隐孢子虫作为免疫治疗剂，使用所引用的剂量。
相似文献
1
Effects of repeated Corynebacterium parvum and BCG therapy on immune parameters: a weekly sequential study of melanoma patients. I. Changes in non-specific (NK, K and T cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions.反复注射短小棒状杆菌和卡介苗治疗对免疫参数的影响：黑色素瘤患者的每周序贯研究。I. 非特异性（自然杀伤细胞、杀伤细胞和T细胞）淋巴细胞毒性、外周血细胞计数及迟发型超敏反应的变化
Clin Exp Immunol. 1979 May;36(2):227-36.
2
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.短小棒状杆菌和卡介苗疗法对播散性黑色素瘤患者免疫参数的影响。一项为期28天的序贯研究。II. 非特异性（自然杀伤细胞、杀伤细胞和T细胞）淋巴细胞毒性及迟发型超敏皮肤反应的变化。
Clin Exp Immunol. 1979 Feb;35(2):171-9.
3
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. I. Changes in blood counts, serum immunoglobulins and lymphoid cell populations.微小棒状杆菌和卡介苗疗法对播散性黑色素瘤患者免疫参数的影响：一项为期28天的序贯研究。I. 血细胞计数、血清免疫球蛋白和淋巴细胞群体的变化
Clin Exp Immunol. 1979 Jan;35(1):36-44.
4
5
Effects of BCG and Corynebacterium parvum on immune reactivity in melanoma patients.卡介苗和短小棒状杆菌对黑色素瘤患者免疫反应性的影响。
Dev Biol Stand. 1977;38:449-53.
6
Effects of diphenylhydantoin on killer cell activity and other immunological functions. A sequential study including the interaction of Corynebacterium parvum in melanoma patients.苯妥英对杀伤细胞活性及其他免疫功能的影响。一项针对黑色素瘤患者的序贯研究，其中包括微小棒状杆菌的相互作用。
Int J Immunopharmacol. 1982;4(3):167-74. doi: 10.1016/0192-0561(82)90045-5.
7
The expression of cytotoxic mediators is altered in mononuclear cells of patients with melanoma and increased by interferon-alpha treatment.黑色素瘤患者单核细胞中细胞毒性介质的表达发生改变，且经α干扰素治疗后会增加。
Br J Dermatol. 2005 Apr;152(4):690-6. doi: 10.1111/j.1365-2133.2005.06512.x.
8
9
Polyvalent melanoma cell vaccine induces delayed-type hypersensitivity and in vitro cellular immune response.多价黑色素瘤细胞疫苗可诱导迟发型超敏反应和体外细胞免疫反应。
Cancer Res. 1994 Jul 1;54(13):3342-5.
引用本文的文献
1
Natural killer cells in human solid tumors.人类实体瘤中的自然杀伤细胞。
Cancer Metastasis Rev. 1983;2(4):337-50. doi: 10.1007/BF00048566.
2
Membrane glycoprotein M-2 protects against Leishmania amazonensis infection.膜糖蛋白M-2可抵御亚马逊利什曼原虫感染。
Infect Immun. 1988 Dec;56(12):3272-9. doi: 10.1128/iai.56.12.3272-3279.1988.
3
Suppression of murine NK activity induced by Corynebacterium parvum: further characterization and abrogation of suppressor cells.微小棒状杆菌诱导的小鼠自然杀伤细胞活性抑制：抑制细胞的进一步特性及消除
Cancer Immunol Immunother. 1986;21(1):51-7. doi: 10.1007/BF00199377.
本文引用的文献
1
Characterization of mononuclear effector cells in human blood.人血中单核效应细胞的特性分析
Clin Exp Immunol. 1976 Jan;23(1):104-13.
2
Changes in cellular immunity following nephrectomy for localized and metastatic hypernephroma.局限性和转移性肾细胞癌肾切除术后细胞免疫的变化。
Eur J Cancer (1965). 1977 Sep;13(9):951-6. doi: 10.1016/0014-2964(77)90171-2.
3
Lymphocyte function related to survival curves in patients with metastatic melanoma treated by chemoimmunotherapy.化学免疫疗法治疗转移性黑色素瘤患者的淋巴细胞功能与生存曲线的关系。
Med Pediatr Oncol. 1978;4(1):59-70. doi: 10.1002/mpo.2950040110.
4
Lymphocyte function and response to chemo-immunotherapy in patients with metastatic melanoma.转移性黑色素瘤患者的淋巴细胞功能及对化学免疫疗法的反应
Br J Cancer. 1977 Dec;36(6):751-62. doi: 10.1038/bjc.1977.258.
5
Effects of Corynebacterium parvum and BCG therapy on immune parameters in patients with disseminated melanoma. A sequential study over 28 days. II. Changes in non-specific (NK, K and T cell) lymphocytoxicity and delayed hypersensitivity skin reactions.短小棒状杆菌和卡介苗疗法对播散性黑色素瘤患者免疫参数的影响。一项为期28天的序贯研究。II. 非特异性（自然杀伤细胞、杀伤细胞和T细胞）淋巴细胞毒性及迟发型超敏皮肤反应的变化。
Clin Exp Immunol. 1979 Feb;35(2):171-9.
6
Sequential in vitro reactivity of lymphocytes from melanoma patients receiving immunotherapy compared with the reactivity of lymphocytes from healthy donors.
Int J Cancer. 1975 Oct 15;16(4):571-8. doi: 10.1002/ijc.2910160407.
Zotero 插件