Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC) , c/Juan de la Cierva, 3 , 28006 Madrid , Spain.
Institut Charles Sadron , Université de Strasbourg, CNRS, UPR 22 , 67034 Strasbourg , France.
Langmuir. 2019 Sep 3;35(35):11397-11405. doi: 10.1021/acs.langmuir.9b01224. Epub 2019 Aug 20.
Alginate/Fe hydrogels were fabricated on hyaluronic acid (HA) and poly(allylamine hydrochloride) (PAH) multilayers to yield photoresponsive nanometer-scale hydrogels. Light irradiation of the resulting hydrogels induced the photoreduction of "hard" Fe to "soft" Fe cations, leading to changes in the mechanical properties of the hydrogels related to their cross-linking behavior. The buildup and the phototriggered response of the supported alginate hydrogels were followed with a quartz crystal microbalance (QCM) using an open cell allowing light irradiation from an LED source on top of the hydrogel. The results were correlated to the release profiles of folic acid, employed herein as a drug model, obtained from light-irradiated supported iron alginate hydrogels.
藻酸盐/Fe 水凝胶是在透明质酸 (HA) 和聚(盐酸烯丙胺) (PAH) 多层上制备的，以得到光响应的纳米级水凝胶。对所得水凝胶进行光照会诱导“硬”Fe 向“软”Fe 阳离子的光还原，从而导致水凝胶的机械性能发生变化，与它们的交联行为有关。使用允许 LED 光源从水凝胶顶部照射的开放单元，通过石英晶体微天平 (QCM) 跟踪负载的藻酸盐水凝胶的构建和光触发响应。结果与光照射负载铁藻酸盐水凝胶中释放的叶酸（本文用作药物模型）的释放曲线相关联。
