σ 受体的分子功能：过去、现在和未来。
The Molecular Function of σ Receptors: Past, Present, and Future.
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Trends Pharmacol Sci. 2019 Sep;40(9):636-654. doi: 10.1016/j.tips.2019.07.006. Epub 2019 Aug 3.
Abstract
The σ and σ receptors are enigmatic proteins that have attracted attention for decades due to the chemical diversity and therapeutic potential of their ligands. However, despite ongoing clinical trials with σ receptor ligands for multiple conditions, relatively little is known regarding the molecular function of these receptors. In this review, we revisit past research on σ receptors and discuss the interpretation of these data in light of recent developments. We provide a synthesis of emerging structural and genetic data on the σ receptor and discuss the recent cloning of the σ receptor. Finally, we discuss the major questions that remain in the study of σ receptors.
摘要
σ 和 σ 受体是神秘的蛋白质，由于其配体的化学多样性和治疗潜力，它们引起了人们数十年的关注。然而，尽管有针对多种疾病的 σ 受体配体的临床试验在进行，但对于这些受体的分子功能相对知之甚少。在这篇综述中，我们回顾了过去关于 σ 受体的研究，并根据最近的发展讨论了这些数据的解释。我们提供了 σ 受体的新兴结构和遗传数据的综合，并讨论了 σ 受体的最近克隆。最后，我们讨论了 σ 受体研究中仍然存在的主要问题。
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