《黑人社群妇女健康研究中非洲裔美国妇女感知的种族主义与端粒长度的关系》
Perceived racism in relation to telomere length among African American women in the Black Women's Health Study.
机构信息
Department of Biostatistics, Boston University School of Public Health, Boston, MA; Slone Epidemiology Center at Boston University, Boston, MA.
Slone Epidemiology Center at Boston University, Boston, MA; Department of Epidemiology, Boston University School of Public Health, Boston, MA.
出版信息
Ann Epidemiol. 2019 Aug;36:33-39. doi: 10.1016/j.annepidem.2019.06.003. Epub 2019 Jun 21.
PURPOSE
Telomere length is considered a biomarker of human aging and premature morbidity and mortality which has been associated with chronic stress.
METHODS
We assessed the relation between perceived racism and telomere length in the Black Women's Health Study, a follow-up study of U.S. black women begun in 1995. Participants were asked about frequency of "everyday racism" (e.g., "people act as if they think you are not intelligent") and "institutional racism" (e.g., "ever treated unfairly due to race by police"). Using quantitative real-time polymerase chain reaction assay, relative telomere lengths (RTL) were measured as the copy number ratio of telomere repeat to a single control gene in 997 participants. Associations of racism variables with log-RTL were estimated by multivariable linear regression, with adjustment for age at blood draw and potential confounders.
RESULTS
Participants were aged 40-70 years (mean = 55.6 years), and mean telomere length was 0.77 (range 0.21-1.38). In stratified analyses, there was an inverse association between everyday racism and log-RTL among women who did not discuss their experiences of racism with others (β = -0.1104; 95% CI = -0.2140 to -0.0067; P = .045).
CONCLUSIONS
Everyday racism was associated with shorter telomere length among women who reported not discussing those experiences with others.
目的
端粒长度被认为是人类衰老和过早发病及死亡的生物标志物，与慢性压力有关。
方法
我们评估了在黑人女性健康研究中，感知到的种族主义与端粒长度之间的关系，这是一项始于 1995 年的美国黑人女性后续研究。参与者被问及“日常种族主义”（例如，“人们表现得好像他们认为你不聪明”）和“制度种族主义”（例如，“由于种族原因被警察不公平对待”）的频率。使用定量实时聚合酶链反应检测，相对端粒长度（RTL）作为端粒重复与单个对照基因的拷贝数比，在 997 名参与者中进行测量。种族主义变量与 log-RTL 的关联通过多变量线性回归进行估计，调整了采血时的年龄和潜在混杂因素。
结果
参与者年龄在 40-70 岁之间（平均年龄 55.6 岁），平均端粒长度为 0.77（范围 0.21-1.38）。在分层分析中，对于不与他人讨论种族主义经历的女性，日常种族主义与 log-RTL 呈负相关（β=-0.1104；95%CI=-0.2140 至-0.0067；P=0.045）。
结论
对于不与他人讨论这些经历的女性，日常种族主义与较短的端粒长度有关。
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