非编码 RNA：调控神经胶质瘤细胞上皮-间充质转化。

Non-coding RNAs: Regulators of glioma cell epithelial-mesenchymal transformation.

机构信息

The Second Affiliated Hospital of Nanchang University, China; Nanchang University, China.

The Second Affiliated Hospital of Nanchang University, China.

出版信息

Pathol Res Pract. 2019 Sep;215(9):152539. doi: 10.1016/j.prp.2019.152539. Epub 2019 Jul 12.

DOI:10.1016/j.prp.2019.152539

PMID:31387808

Abstract

GBM (glioblastoma multiforme) is the most malignant form of glioma and is the most commonly occurring primary malignant brain tumour. GBM is difficult to completely excise, resulting in an extremely high recurrence rate. The occurrence of an aggressive glioma phenotype depends on EMT (epithelial-mesenchymal transformation), in which epithelial cells transform into mesenchymal cells by losing their cell-cell adhesion and polarity. NcRNAs (non-coding RNAs) play a significant role in the cellular progression from a normal phenotype to a cancerous phenotype. Recently, many studies have shown that there are two essential regulatory ncRNAs, miRNAs (microRNAs) and lncRNAs, which are closely related to EMT. In this review, we conducted a comprehensive investigation of the dysregulated lncRNAs and miRNAs in gliomas with particular attention to the function and regulatory mechanisms of several important lncRNAs and miRNAs, and we discussed their roles as glioma diagnostic and prognostic biomarkers and their potential clinical applications as therapeutic targets.

摘要

GBM（多形性胶质母细胞瘤）是最恶性的神经胶质瘤，也是最常见的原发性恶性脑肿瘤。GBM 很难完全切除，导致复发率极高。侵袭性神经胶质瘤表型的发生依赖于 EMT（上皮-间充质转化），上皮细胞通过失去细胞间黏附和极性转化为间充质细胞。ncRNAs（非编码 RNA）在细胞从正常表型向癌变表型的进展中起着重要作用。最近，许多研究表明，有两种重要的调控 ncRNAs，miRNAs（microRNAs）和 lncRNAs，与 EMT 密切相关。在这篇综述中，我们对胶质瘤中失调的 lncRNAs 和 miRNAs 进行了全面研究，特别关注了几种重要的 lncRNAs 和 miRNAs 的功能和调控机制，并讨论了它们作为神经胶质瘤诊断和预后生物标志物的作用，以及作为治疗靶点的潜在临床应用。