Chen Mengyu, Yan Chunyan, Zhao Xihe
Department of Clinical Oncology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Oncol. 2021 Oct 21;11:705059. doi: 10.3389/fonc.2021.705059. eCollection 2021.
The discovery of circular RNA (circRNA) greatly complements the traditional gene expression theory. CircRNA is a class of non-coding RNA with a stable cyclic structure. They are highly expressed, spatiotemporal-specific and conservative across species. Importantly, circRNA participates in the occurrence of many kinds of tumors and regulates the tumor development. Glioma is featured by limited therapy and grim prognosis. Cancer-associated circRNA compromises original function or creates new effects in glioma, thus contributing to oncogenesis. Therefore, this article reviews the biogenesis, metabolism, functions and properties of circRNA as a novel potential biomarker for gliomas. We elaborate the expression characteristics, interaction between circRNA and other molecules, aiming to identify new targets for early diagnosis and treatment of gliomas.
环状RNA（circRNA）的发现极大地补充了传统基因表达理论。circRNA是一类具有稳定环状结构的非编码RNA。它们在物种间高度表达、具有时空特异性且保守。重要的是，circRNA参与多种肿瘤的发生并调节肿瘤发展。胶质瘤的特点是治疗手段有限且预后严峻。癌症相关的circRNA在胶质瘤中损害原有功能或产生新作用，从而促进肿瘤发生。因此，本文综述了circRNA作为胶质瘤一种新型潜在生物标志物的生物合成、代谢、功能及特性。我们阐述了circRNA的表达特征、circRNA与其他分子之间的相互作用，旨在为胶质瘤的早期诊断和治疗确定新靶点。
