新生儿卡介苗接种与儿童期分枝杆菌性颈淋巴结炎

Neonatal BCG vaccination and mycobacterial cervical adenitis in childhood.

作者信息

Katila M L, Brander E, Backman A

机构信息

Kuopio University Central Hospital, Department of Clinical Microbiology, Finland.

出版信息

Tubercle. 1987 Dec;68(4):291-6. doi: 10.1016/0041-3879(87)90070-5.

DOI:10.1016/0041-3879(87)90070-5

PMID:3138802

Abstract

Mycobacterial cervical adenitis is an uncommon disease in children in Finland. During 10 years, from 1977-1986, its incidence was of the order of 0.3/year/100,000 children. Of the 12 bacteriologically verified cases, M. avium-intracellulare was isolated in nine, M. malmoense in two and M. tuberculosis in only one case. Neonatal BCG vaccination seemed to protect children against non-tuberculous mycobacterial infection, especially at 1-4 years of age. In Sweden, where neonatal BCG vaccination has been discontinued, the incidence of non-tuberculous mycobacterial adenitis is at least 30 times greater.

摘要

分枝杆菌性颈淋巴结炎在芬兰儿童中是一种罕见疾病。在1977年至1986年的10年间，其发病率约为每年每10万名儿童中有0.3例。在12例经细菌学证实的病例中，9例分离出鸟分枝杆菌-胞内分枝杆菌，2例分离出马尔默分枝杆菌，仅1例分离出结核分枝杆菌。新生儿卡介苗接种似乎能保护儿童免受非结核分枝杆菌感染，尤其是在1至4岁时。在已停止新生儿卡介苗接种的瑞典，非结核分枝杆菌性淋巴结炎的发病率至少高出30倍。