Asćerić Mensura, Nadarević Alma, Avdić Sevleta, Vrabac-Mujcinagić Muamera, Nukić Sabrija, Mujcinović Zulfo
Department of Pharmacology and Toxicology, University of Tuzla, School of Medicine, Univerzitetska 1, 75000 Tuzla, Bosnia and Herzegovina.
Bosn J Basic Med Sci. 2007 Aug;7(3):218-21. doi: 10.17305/bjbms.2007.3047.
Hexagon TB is intended for the rapid diagnostics of tuberculosis. Tuberculosis is a contagious and epidemic disease. According to the data published by WHO, 3-4 millions of patients are diagnosed with this disease annually. In 2004, 107 new cases were discovered in the area of Tuzla Municipality. Annual incidence of this disease is 62,9 per 100 000 inhabitants in Bosnia and Herzegovina; 28,9 in Slovenia; 33,2 in FYRM; 48,5 in Croatia; 41,8 in Serbia and Montenegro. Western European countries have a rather low rate of the disease--5-10 cases per 100 000 inhabitants. Efficiency of Hexagon TB examination method was tested on 100 patients. The subjects were patients with clinical symptoms of active TBC infection, persons who were in contact with TBC patients and persons earlier cured of TBC. All the subjects were tested with Hexagon TB, and the results were compared against lungs X-rays and sputum test for BK and LOW. Hexagon TB is intended for rapid, qualitative detection of IgG, IgA, IgM antibodies against M. tuberculosis and mycobacterium in human serum, plasma or whole blood as an aid in the early diagnostics of tuberculosis infections for professional use. Hexagon TB was positive in 11 of the examined patients. 10 patients had changes suggesting TBC. 1 patient was directly positive for BK and 3 patients were positive for LOW. Of all the examined patients, 3 were positive for all tests positive. According to our results, Hexagon TB has significant importance in practice of rapid TBC diagnostics compared to lungs X-ray and examination of sputum for BK and LOW.
“六角形结核检测法”旨在快速诊断结核病。结核病是一种传染性流行病。根据世界卫生组织公布的数据,每年有300万至400万患者被诊断出患有这种疾病。2004年,在图兹拉市地区发现了107例新病例。在波斯尼亚和黑塞哥维那,这种疾病的年发病率为每10万居民62.9例;在斯洛文尼亚为28.9例;在马其顿为33.2例;在克罗地亚为48.5例;在塞尔维亚和黑山为41.8例。西欧国家的发病率相当低,每10万居民中有5至10例。“六角形结核检测法”的检测效率在100名患者身上进行了测试。这些受试者包括有活动性结核感染临床症状的患者、与结核病患者有接触的人以及先前已治愈结核病的人。所有受试者都接受了“六角形结核检测法”检测,并将结果与肺部X光检查以及BK和LOW痰液检测结果进行了比较。“六角形结核检测法”旨在快速、定性地检测人血清、血浆或全血中针对结核分枝杆菌和分枝杆菌的IgG、IgA、IgM抗体,作为专业用途的结核病感染早期诊断辅助手段。在接受检测的患者中,有11人“六角形结核检测法”呈阳性。10名患者有提示结核病的变化。1名患者BK直接呈阳性,3名患者LOW呈阳性。在所有接受检测的患者中,有3人所有检测均呈阳性。根据我们的结果,与肺部X光检查以及BK和LOW痰液检查相比,“六角形结核检测法”在结核病快速诊断实践中具有重要意义。