Mussa Bashair M, Schauman Mia, Kumar Vijay, Skaria Sijomol, Abusnana Salah
Basic Medical Science Department, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.
Medical Research Department, Celolab, Dubai, United Arab Emirates.
Diabetes Metab Syndr Obes. 2019 Jun 28;12:991-999. doi: 10.2147/DMSO.S201142. eCollection 2019.
There is growing evidence that stress and sleep deprivation are involved in development of type 2 diabetes (T2DM). The latter is one of the most challenging health problems in the UAE. Therefore, the present study aimed to investigate the effects of personalized intervention on glycemic and weight control in Emirati patients with T2DM. The intervention involved assessment and modification of stress levels and sleep patterns. This was a randomized controlled study conducted on 51 Emirati patients with T2DM (age 18-60 years, body-mass index (BMI) ≥25 kg/m): those in the intervention group who completed the trial numbered 18 and those in the control group who completed the trial numbered 17. Heart-rate variability was used for real-life and long-term assessments of stress, sleep, and recovery. Body weight, BMI, HbA and lipid profile were included in the investigation. The National Clinical Trial identifier number is NCT03644134. Percentage change in body weight was significantly greater (<0.05) in the intervention group (-3.2±2.9) than the control group (-0.02). Percentage change in the BMI of the intervention group was -4.50±5.9, while the control group exhibited less change in BMI (-0.0003±3.3, <0.05). In addition, a significant reduction in HbA was observed in the intervention group (-5.3±15.7) and an increase of 9.9±13.1 was observed in the control group (<0.01). The findings of the present study show that personalized approaches that reduce stress levels, increase recovery levels, and promote healthy sleep habits play an important role in weight management and glycemic control in T2DM.
越来越多的证据表明，压力和睡眠不足与2型糖尿病（T2DM）的发生发展有关。后者是阿联酋最具挑战性的健康问题之一。因此，本研究旨在调查个性化干预对阿联酋T2DM患者血糖和体重控制的影响。该干预包括评估和调整压力水平及睡眠模式。这是一项对51名阿联酋T2DM患者（年龄18 - 60岁，体重指数（BMI）≥25 kg/m）进行的随机对照研究：干预组完成试验的有18人，对照组完成试验的有17人。心率变异性用于对压力、睡眠和恢复进行现实生活和长期评估。调查包括体重、BMI、糖化血红蛋白（HbA）和血脂谱。国家临床试验标识符编号为NCT03644134。干预组体重的百分比变化（-3.2±2.9）显著大于（<0.05）对照组（-0.02）。干预组BMI的百分比变化为-4.50±5.9，而对照组BMI变化较小（-0.0003±3.3，<0.05）。此外，干预组的HbA显著降低（-5.3±15.7），而对照组升高了9.9±13.1（<0.01）。本研究结果表明，降低压力水平、提高恢复水平并促进健康睡眠习惯的个性化方法在T2DM的体重管理和血糖控制中发挥着重要作用。
