Çetin M, Erdoğan T, Kırış T, Özer S, Yılmaz A S, Durak H, Aykan A Ç, Şatıroğlu Ö
Faculty of Medicine, Department of Cardiology, Recep Tayyip Erdogan University, Rize, Turkey.
Ataturk Training and Research Hospital, Department of Cardiology, Izmir Katip Celebi University, Izmir, Turkey.
Herz. 2020 Dec;45(Suppl 1):145-151. doi: 10.1007/s00059-019-4840-5. Epub 2019 Aug 6.
We aimed to investigate the predictive value of the fibrinogen-to-albumin ratio (FAR) regarding the development of major cardiovascular events (MACE) in patients treated with percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS).
This was a prospective, observational cohort study that included 261 consecutive patients who were treated with PCI. The patients were grouped according to the occurrence of MACE during the follow-up period.
During follow-up, MACE occurred in 68 (26%) patients. The FAR was independently predictive of MACE (HR: 1.017, 95% CI: 1.010-1.024, p < 0.001). In addition, left ventricular ejection fraction (LVEF) and a diagnosis of ST-segment elevation myocardial infarction (STEMI) were independent predictors of MACE. The area under the curve (AUC) of the multivariable model, including LVEF and diagnosis of STEMI, was 0.707 (95% CI: 0.631-0.782, p < 0.001). When the FAR was added to the multivariable model, the AUC was 0.770 (95% CI: 0.702-0.838, z = 2.820, difference p = 0.0048).
The FAR could be used for the prediction of MACE in patients with ACS who have undergone PCI.
我们旨在研究纤维蛋白原与白蛋白比值（FAR）对接受经皮冠状动脉介入治疗（PCI）的急性冠状动脉综合征（ACS）患者发生主要心血管事件（MACE）的预测价值。
这是一项前瞻性观察队列研究，纳入了261例连续接受PCI治疗的患者。根据随访期间MACE的发生情况对患者进行分组。
随访期间，68例（26%）患者发生了MACE。FAR是MACE的独立预测指标（HR：1.017，95%CI：1.010-1.024，p＜0.001）。此外，左心室射血分数（LVEF）和ST段抬高型心肌梗死（STEMI）诊断是MACE的独立预测因素。包含LVEF和STEMI诊断的多变量模型的曲线下面积（AUC）为0.707（95%CI：0.631-0.782，p＜0.001）。当将FAR添加到多变量模型中时，AUC为0.770（95%CI：0.702-0.838，z = 2.820，差异p = 0.0048）。
FAR可用于预测接受PCI的ACS患者发生MACE的情况。
