Ali Nilufar, Beheshti Afshin, Hampikian Greg
Department of Biological Science, Boise State University, Boise, ID, 83725, USA.
McGowan Institute for Regenerative Medicine - Center for Space Biomedicine, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
NPJ Microgravity. 2025 Jan 3;11(1):1. doi: 10.1038/s41526-024-00457-6.
Systemic mitochondrial dysfunction, dopamine loss, sustained structural changes in the basal ganglia including reduced tyrosine hydroxylase, and altered gait- these effects observed in space-flown animals and astronauts mirrors Parkinson's disease (PD). Evidence of mitochondrial changes in space-flown human cells, examined through the lens of PD, suggests that spaceflight-induced PD-like molecular changes are important to monitor during deep space exploration. These changes, may potentially elevate the risk of PD in astronauts.
全身线粒体功能障碍、多巴胺丧失、基底神经节持续的结构变化（包括酪氨酸羟化酶减少）以及步态改变——在太空飞行的动物和宇航员身上观察到的这些效应与帕金森病（PD）相似。通过帕金森病的视角研究太空飞行的人类细胞中线粒体变化的证据表明，在深空探索期间监测太空飞行引起的类似帕金森病的分子变化很重要。这些变化可能会增加宇航员患帕金森病的风险。
