Laskar Roshayed Ali, Yoshikai Naohiko
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences , Nanyang Technological University , Singapore 637371 , Singapore.
J Org Chem. 2019 Oct 18;84(20):13172-13178. doi: 10.1021/acs.joc.9b01775. Epub 2019 Aug 20.
A cobalt-catalyzed -C-H benzylation reaction of pivalophenone N-H imines with benzyl phosphates is reported. The reaction is promoted at room temperature by a ternary catalytic system comprising Co(acac), a pyridylphosphine ligand, and a Grignard reagent and tolerates a series of substituted pivalophenone imines and benzyl phosphates to afford various diarylmethane derivatives in moderate yields.
报道了一种钴催化新戊苯乙酮N-H亚胺与苄基磷酸酯的-C-H苄基化反应。该反应在室温下由包含Co(acac)、吡啶基膦配体和格氏试剂的三元催化体系促进，并且能耐受一系列取代的新戊苯乙酮亚胺和苄基磷酸酯，以中等产率得到各种二芳基甲烷衍生物。
