Takahashi Naoki, Sulijaya Benso, Yamada-Hara Miki, Tsuzuno Takahiro, Tabeta Koichi, Yamazaki Kazuhisa
Division of Periodontology, Department of Oral Biological Science, Faculty of Dentistry, Niigata University , Niigata , Japan.
Research Center for Advanced Oral Science, Graduate School of Medical and Dental Sciences, Niigata University , Niigata , Japan.
Tissue Barriers. 2019;7(3):e1651158. doi: 10.1080/21688370.2019.1651158. Epub 2019 Aug 7.
The gingival epithelium acts as a physical barrier to separate the biofilm from the gingival tissue, providing the first line of defense against bacterial invasion in periodontal disease. Disruption of the gingival epithelial barrier, and the subsequent penetration of exogenous pathogens into the host tissues, triggers an inflammatory response, establishing chronic infection. Currently, more than 700 different bacterial species have been identified in the oral cavity, some of which are known to be periodontopathic. These bacteria contribute to epithelial barrier dysfunction in the gingiva by producing several virulence factors. However, some bacteria in the oral cavity appear to be beneficial, helping gingival epithelial cells maintain their integrity and barrier function. This review aims to discuss current findings regarding microorganism interactions and epithelial barrier function in the oral cavity, with reference to investigations in the gut, where this interaction has been extensively studied.
牙龈上皮作为一道物理屏障，将生物膜与牙龈组织分隔开来，构成了抵御牙周疾病中细菌入侵的第一道防线。牙龈上皮屏障的破坏以及随后外源性病原体侵入宿主组织，会引发炎症反应，导致慢性感染。目前，口腔中已鉴定出700多种不同的细菌物种，其中一些已知是牙周病致病菌。这些细菌通过产生多种毒力因子导致牙龈上皮屏障功能障碍。然而，口腔中的一些细菌似乎是有益的，有助于牙龈上皮细胞维持其完整性和屏障功能。本综述旨在讨论关于口腔中微生物相互作用和上皮屏障功能的当前研究结果，并参考在肠道中已被广泛研究的这种相互作用的相关调查。
