Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Dermatology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Dermatol Venereol Leprol. 2019 Sep-Oct;85(5):567. doi: 10.4103/ijdvl.IJDVL_392_18.
Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and incomplete differentiation of epidermis, and accumulation of neutrophils and proinflammatory T cells in epidermis and dermis. Chemokines are believed to be the main players mediating the chemotaxis of leucocytes to the lesional site. Previous studies have established the role of various chemokine ligands and receptors at the lesional site in psoriasis.
In this study, we have compared the serum levels of various chemokines, namely, inducible protein-10 (IP-10) (CXCL10), MCP-1 (CCL-2), monokine induced by gamma interferon (MIG) (CXCL-9), RANTES (CCL5), interleukin (IL)-8, and eotaxin in patients with chronic plaque psoriasis with that of healthy controls. We also studied whether the chemokine levels varied within different patient groups based on various clinical and demographic parameters, and if any of these chemokines correlated with disease activity.
We studied 40 patients with chronic plaque psoriasis from a single center. Their clinical and demographic details were recorded in predesigned prforma. Patients with unstable forms of psoriasis like guttate, erythrodermic, or pustular psoriasis were excluded. The serum chemokine levels were measured by flow cytometry-based bead array set system. The serum levels of the patients were compared with that of 25 healthy controls. A subgroup analysis was also done to study the correlation of chemokine levels with age, sex, duration, and severity of disease.
We observed a significant decrease in serum level of all these chemokines in patients, when compared with that of healthy controls. We also found that MIG levels showed a positive correlation with disease severity based on Psoriasis Area and Severity Index.
The major limitation of the study is lack of data on the lesional chemokine levels compared to serum chemokines.
The inflammatory process in psoriasis is orchestrated through chemokines. MIG is a potential serum biomarker for assessing disease severity.
银屑病是一种慢性炎症性皮肤病，其特征为表皮过度增生和不完全分化，以及中性粒细胞和促炎 T 细胞在表皮和真皮中的积聚。趋化因子被认为是介导白细胞向病变部位趋化的主要参与者。先前的研究已经确定了银屑病病变部位各种趋化因子配体和受体的作用。
在这项研究中，我们比较了慢性斑块型银屑病患者与健康对照组的各种趋化因子，即诱导蛋白-10（IP-10）（CXCL10）、单核细胞趋化蛋白-1（MCP-1）（CCL-2）、γ干扰素诱导的单核细胞趋化蛋白（MIG）（CXCL-9）、调节激活正常 T 细胞表达分泌因子（RANTES）（CCL5）、白细胞介素（IL）-8 和嗜酸性粒细胞趋化因子在患者中的血清水平。我们还研究了这些趋化因子水平是否根据不同的临床和人口统计学参数在不同的患者组中发生变化，以及这些趋化因子中的任何一种是否与疾病活动度相关。
我们从一个单一的中心研究了 40 名患有慢性斑块型银屑病的患者。他们的临床和人口统计学细节都记录在预设计的表格中。排除了不稳定型银屑病（如点滴状、红皮病型或脓疱型银屑病）的患者。通过流式细胞术基于珠阵列系统测量血清趋化因子水平。将患者的血清水平与 25 名健康对照者进行比较。还进行了亚组分析，以研究趋化因子水平与年龄、性别、病程和疾病严重程度的相关性。
与健康对照组相比，我们观察到患者血清中所有这些趋化因子的水平均显著降低。我们还发现，根据银屑病面积和严重程度指数（PASI），MIG 水平与疾病严重程度呈正相关。
该研究的主要局限性是缺乏与血清趋化因子相比的病变部位趋化因子水平的数据。
银屑病的炎症过程是通过趋化因子协调的。MIG 是评估疾病严重程度的潜在血清生物标志物。
