Zhao Pan, Zhang Jing, Liu Biyong, Tang Yufei, Wang Lei, Wang Guifeng, Wu Huihui, Yang Chengwei, Li Xuemei, Li Bo
Anhui Prevention and Treatment Center for Occupational Disease, Anhui No. 2 Provincial People's Hospital, Hefei, China.
Front Genet. 2022 Jun 13;13:941961. doi: 10.3389/fgene.2022.941961. eCollection 2022.
Psoriasis vulgaris is an inflammatory skin disease. Observational studies have shown associations between circulating cytokine levels and psoriasis vulgaris. But the causal relationship between circulating cytokine and psoriasis vulgaris remains elusive. To assess the causal effects of cytokine levels on the risk of psoriasis vulgaris and vice versa, we performed a two-sample Mendelian randomization (MR) study by using the inverse-variance weighted (IVW), weighted median, and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) in genome-wide association summary statistics of 41 circulating cytokines in up to 8,293 individuals and psoriasis vulgaris in 399,883 individuals. We identified that increasing RANTES level induced an elevated risk of psoriasis vulgaris in IVW ( = 0.33, S.E. = 0.12, = 0.006). This causal effect showed consistency across the weighted median ( = 0.35, S.E. = 0.15, = 0.022) and MR-PRESSO method ( = 0.33, S.E. = 0.11, = 0.028). Our results suggest a potential causal effect of elevated RANTES concentration on the increased risk of psoriasis vulgaris.
寻常型银屑病是一种炎症性皮肤病。观察性研究表明循环细胞因子水平与寻常型银屑病之间存在关联。但循环细胞因子与寻常型银屑病之间的因果关系仍不明确。为了评估细胞因子水平对寻常型银屑病风险的因果效应，反之亦然，我们通过在多达8293名个体的41种循环细胞因子和399883名个体的寻常型银屑病的全基因组关联汇总统计中使用逆方差加权（IVW）、加权中位数和孟德尔随机化多效性残差和离群值（MR-PRESSO）进行了一项两样本孟德尔随机化（MR）研究。我们发现在IVW中，RANTES水平升高会导致寻常型银屑病风险升高（比值比 = 0.33，标准误 = 0.12，P = 0.006）。这种因果效应在加权中位数（比值比 = 0.35，标准误 = 0.15，P = 0.022）和MR-PRESSO方法（比值比 = 0.33，标准误 = 0.11，P = 0.028）中表现出一致性。我们的结果表明RANTES浓度升高对寻常型银屑病风险增加存在潜在因果效应。
