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[配体对DNA碱基中AT对和GC对的选择性作用]

[Selective effect of ligands on AT- and GC-pairs of DNA bases].

作者信息

Aslanian V M, Arutiunian S G, Lando D Iu, Dalian E B, Shpokovskiĭ A G

出版信息

Biofizika. 1988 May-Jun;33(3):430-6.

PMID:3139047
Abstract

A method is proposed for investigating the specific influence of ligands on DNA AT- and GC-pairs based on the comparison of the width of transition temperature interval of DNA with a strongly pronounced block-structure and dependence of the control DNA melting temperature on their GC-content. Such a comparison allows to define separately the contribution of nonspecific effects causing a change of the width of transition temperature interval. The method is used for studying the specific influence of beta-alanine and nu-aminobutyric acid on AT- and GC-pairs.

摘要

提出了一种基于对具有明显块状结构的DNA转变温度区间宽度以及对照DNA解链温度对其GC含量的依赖性进行比较，来研究配体对DNA AT对和GC对的特定影响的方法。这种比较能够分别确定导致转变温度区间宽度变化的非特异性效应的贡献。该方法用于研究β-丙氨酸和γ-氨基丁酸对AT对和GC对的特定影响。

相似文献

1
[Selective effect of ligands on AT- and GC-pairs of DNA bases].[配体对DNA碱基中AT对和GC对的选择性作用]
Biofizika. 1988 May-Jun;33(3):430-6.
2
[Selective effect of ionization of nitrogen bases on the thermostability of AT- and GC-pairs of DNA].[氮碱基电离对DNA中AT对和GC对热稳定性的选择性影响]
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[Influence of ligands characteristic of selective binding to a certain type of base pairs on DNA helix-coil transition I. Model. Theory].[特定类型碱基对选择性结合配体对DNA螺旋-线圈转变的影响I.模型.理论]
Mol Biol (Mosk). 1979 Sep-Oct;13(5):1098-109.
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引用本文的文献

1
A method for determining the relative effect of ligands on A-T and G-C base pairs in DNA: applications to metal ions, protons and two amino acids.一种确定配体对DNA中A-T和G-C碱基对相对影响的方法：应用于金属离子、质子和两种氨基酸。
Nucleic Acids Res. 1990 Nov 11;18(21):6413-7. doi: 10.1093/nar/18.21.6413.