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手性自由基加成/交叉偶联反应：有机锌试剂、烷基碘化物和烯基硼试剂。

Enantioselective Radical Addition/Cross-Coupling of Organozinc Reagents, Alkyl Iodides, and Alkenyl Boron Reagents.

机构信息

Department of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA, 02467, USA.

出版信息

Angew Chem Int Ed Engl. 2019 Oct 1;58(40):14245-14249. doi: 10.1002/anie.201908029. Epub 2019 Aug 28.

DOI:10.1002/anie.201908029
PMID:31390474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6764867/
Abstract

A hybrid transition-metal/radical process is described that results in the addition of organozinc reagents and alkyl halides across alkenyl boron reagents in an enantioselective catalytic fashion. The reaction can be accomplished both intermolecularly and intramolecularly, providing useful product yields and high enantioselectivities in both manifolds.

摘要

一种杂化过渡金属/自由基过程被描述为，在对映选择性催化条件下，通过有机锌试剂和卤代烷烃与烯基硼试剂加成。该反应可以在分子间和分子内进行，在两种情况下都提供了有用的产物收率和高对映选择性。

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