Bassareo Pier Paolo, Cocco Daniele, Cadeddu Christian, Mercuro Giuseppe
Department of Cardiology, University College of Dublin, Mater Misericordiae University Hospital, Dublin, Republic of Ireland, Monserrato, Italy.
Department of Medical Sciences and Public Health, University of Cagliari, Monserrato, Italy.
J Cardiovasc Echogr. 2019 Apr-Jun;29(2):71-74. doi: 10.4103/jcecho.jcecho_12_19.
Cancer and chemotherapy are known to be risk factors for developing coagulative disorders, venous thrombosis, adverse cardiovascular events, and cardiotoxicity. Combined modality gemcitabine-cisplatin chemotherapy is often administered to treat a few solid tumors. We report the unusual case of a man suffering from urothelial cancer and admitted for chemotherapy, who developed an ischemic stroke after the last chemotherapeutical cycle. During his hospital stay, at echocardiographic examination, left ventricular transient hypokinesia and two intraventricular thrombi were detected, without evidence of acute coronary syndrome. Multimodality imaging approach (i.e., transthoracic echo, transoesophageal echo, computed tomography, and cardiac magnetic resonance imaging) played a pivotal role for a clear diagnosis and prompt decision-making. This is the first report of an intraventricular-related arterial thromboembolic event in a patient treated with the combination gemcitabine-cisplatin.
癌症和化疗是已知的导致凝血障碍、静脉血栓形成、不良心血管事件和心脏毒性的风险因素。吉西他滨-顺铂联合化疗常用于治疗一些实体瘤。我们报告了一例患有尿路上皮癌并入院接受化疗的男性患者的罕见病例，该患者在最后一个化疗周期后发生了缺血性中风。在他住院期间，经超声心动图检查，发现左心室短暂运动功能减退和两个心室内血栓，无急性冠状动脉综合征的证据。多模态成像方法（即经胸超声心动图、经食管超声心动图、计算机断层扫描和心脏磁共振成像）对明确诊断和迅速决策起到了关键作用。这是首例关于接受吉西他滨-顺铂联合治疗的患者发生的心室内相关动脉血栓栓塞事件的报告。
