Department of Neurology, Barzilai University Medical Center, Ashkelon, Israel.
Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel.
Acta Neurol Scand. 2019 Nov;140(5):366-371. doi: 10.1111/ane.13154. Epub 2019 Sep 9.
Previous studies showed concordance between the typical Periodic Sharp Wave Complex (PSWC) activity in EEG of Creutzfeldt-Jakob Disease (CJD) patients and the MRI findings, while the concordance with slow activity in EEG is less established. The aim of this study was to better characterize the association between MRI findings and EEG changes using quantitative EEG (qEEG) analysis.
The demographics, clinical features, and the MRI findings of 12 familial E200K patients with CJD were gathered. EEG test was done and reviewed for the typical PSWC and for the non-specific slow activity. A possible association between the MRI findings and the EEG activity was examined. Then, EEG was analyzed using qEEG tool, and the association between the qEEG finding and the MRI was examined.
Twelve patients were included in the study (67% women). Cortical MRI lesions finding were seen in 6/12 (50%) of the patients, and deep gray mater lesions were seen in 8/12 patients (67%). EEG showed the classic PSWC in 6/12 (50%) of the patients where slow activity was seen in 10/12 (83%). Slow activity and cortical MRI findings were associated in only 2/6 (33%) where deep gray matter findings and the slow activity had concordance of 4/8 (50%). qEEG analysis improved this concordance between slow activity and cortical findings to 3/6 (50%) and with the deep gray matter findings to 5/8 (63%).
Quantitative EEG analysis modesty but not significantly, improves the association of EEG slow activity in familial E200K CJD patients with MRI findings.
先前的研究表明，克雅氏病（CJD）患者脑电图中的典型周期性尖波复合波（PSWC）活动与 MRI 发现之间存在一致性，而与脑电图中的慢波活动之间的一致性则不太确定。本研究的目的是使用定量脑电图（qEEG）分析更好地描述 MRI 发现与脑电图变化之间的关联。
收集了 12 例家族性 E200K 克雅氏病患者的人口统计学、临床特征和 MRI 发现。对脑电图测试进行了检查，并对典型 PSWC 和非特异性慢波活动进行了复查。检查了 MRI 发现与 EEG 活动之间的可能关联。然后，使用 qEEG 工具对脑电图进行了分析，并检查了 qEEG 发现与 MRI 之间的关联。
研究纳入了 12 例患者（67%为女性）。6/12（50%）例患者的皮质 MRI 病变发现，8/12（67%）例患者的深部灰质病变发现。6/12（50%）例患者的脑电图显示典型 PSWC，10/12（83%）例患者的脑电图显示慢波活动。只有 2/6（33%）例患者的慢波活动与皮质 MRI 发现相关，而深部灰质发现与慢波活动的一致性为 4/8（50%）。qEEG 分析将慢波活动与皮质发现之间的一致性提高到 3/6（50%），与深部灰质发现之间的一致性提高到 5/8（63%）。
定量脑电图分析适度但无显著提高家族性 E200K 克雅氏病患者脑电图慢波活动与 MRI 发现之间的关联。
