Department of Neurology, Suqian First People's Hospital, Suqian 223800, Jiangsu, China.
Department of Imaging, Suqian First People's Hospital, Suqian 223800, Jiangsu, China.
Contrast Media Mol Imaging. 2021 Aug 3;2021:2120130. doi: 10.1155/2021/2120130. eCollection 2021.
This paper aimed to explore the clinical value of combined adoption of magnetic resonance diffusion tensor imaging (DTI) and quantitative electroencephalogram (QEEG) in assessing microstructure changes and mild neurocognitive dysfunction in patients with white matter demyelination. 128 cases of white matter demyelination admitted to the hospital from October 2018 to October 2019 were rolled into the research group, and 100 healthy patients physically examined during the same period were rolled into the control (ctrl) group. QEEG and magnetic resonance DTI examinations were performed for all patients. The wave power of , , , and and the ratio of / and ( + )/( + ) were recorded. The FA values of white matter fibers in different brain areas were measured, and the Montreal Cognitive Assessment (MoCA) and Addenbrooke Cognitive Evaluation rating (ACE-R) were adopted to assess the neurocognitive function of patients. It was found that the dominant frequency of each brain area in the research group was 8-9 Hz slow wave. In contrast with the ctrl, the wave and / values in the research group were lower, while wave and + / + values were higher ( < 0.05); the scores of ACE-R and MoCA were lower ( < 0.01); the fractional anisotropy (FA) values of the right frontal lobe white matter (0.335 ± 0.068), the left temporal lobe white matter (0.391 ± 0.032), and the corpus callosum knee white matter (0.658 ± 0.053) were lower ( < 0.05). The FA values of these three areas were positively correlated with attention and calculation, memory, and memory of MoCA scale, respectively ( < 0.05). The FA value of the right frontal white matter was positively correlated with the attention and calculation score of the ACE-R scale ( < 0.05). In conclusion, magnetic resonance DTI combined with QEEG could reflect the microstructural changes of white matter, which may be associated with mild neurocognitive impairment. The primary objective of the study was to explore the clinical value of combined adoption of magnetic resonance DTI and QEEG in assessing microstructure changes and mild neurocognitive dysfunction in patients with white matter demyelination, expected to provide a theoretical basis for the treatment of white matter demyelination.
本文旨在探讨磁共振弥散张量成像（DTI）和定量脑电图（QEEG）联合应用于评估脱髓鞘性白质病患者微观结构变化和轻度神经认知功能障碍的临床价值。将 2018 年 10 月至 2019 年 10 月期间收治的 128 例脱髓鞘性白质病患者纳入研究组，同期体检的 100 例健康患者纳入对照组（ctrl）。对所有患者进行 QEEG 和磁共振 DTI 检查。记录 、 、 、 波功率和 / 及（ + ）/（ + ）比值。测量不同脑区白质纤维的 FA 值，并采用蒙特利尔认知评估（MoCA）和 Addenbrooke 认知评估评分（ACE-R）评估患者的神经认知功能。结果发现，研究组各脑区优势频率为 8-9Hz 慢波。与对照组相比，研究组 波和 / 值较低，而 波和 + / + 值较高（ < 0.05）；ACE-R 和 MoCA 评分较低（ < 0.01）；右侧额叶白质（0.335 ± 0.068）、左侧颞叶白质（0.391 ± 0.032）和胼胝体膝部白质（0.658 ± 0.053）FA 值较低（ < 0.05）。这三个区域的 FA 值与 MoCA 量表的注意力和计算能力、记忆力和记忆分别呈正相关（ < 0.05）。右侧额叶白质的 FA 值与 ACE-R 量表的注意力和计算能力评分呈正相关（ < 0.05）。总之，磁共振 DTI 联合 QEEG 可反映白质微观结构变化，可能与轻度神经认知障碍有关。本研究的主要目的是探讨磁共振 DTI 联合 QEEG 评估脱髓鞘性白质病患者微观结构变化和轻度神经认知功能障碍的临床价值，为脱髓鞘性白质病的治疗提供理论依据。
