Sundblad Alberto S, Ricci Lila, Xynos Francisco P, Fernandez-Pol J Alberto
Departments of Pathology, Division of Breast Cancer Screening/Surgery, Hospital Privado de Comunidad, Mar del Plata, Argentina.
Biostatistics Department, Facultad de Ciencias Exactas, National University of Mar del Plata, Mar del Plata, Argentina.
Cancer Genomics Proteomics. 2005 Jan-Feb;2(1):53-60. Epub 2005 Jan 1.
Metallopanstimulin (MPS-1)/S27 ribosomal protein is involved in cellular proliferation and oncogenesis. In this study, we have examined the expression of the MPS-1 protein in 120 stages I and II breast carcinomas to study its relationship with breast cancer prognosis. We also determined if there was any relationship of MPS-1 with other biological markers commonly used in breast cancer prognosis. The expression of MPS-1 protein was analyzed by immunohistochemistry using specific anti-MPS-1 antibodies. We found that there was greater expression of MPS-1 in tumors of greater size and in higher histological grades. Thus, in tumors with more histological aggressiveness there is more MPS-1. Both were frequently associated with a greater proliferative activity. There was also a significant association between the expression of MPS-1 with the expression of receptors for progesterone (p=0.004), estrogens (p=0.03), bcl-2 (p=0.002), and MIB-1 (p=0.03). After univariate logistic regression analysis, we found that overexpression of MPS-1 correlated with Disease Free Survival (DFS) (p=0.039), showing that MPS-1 positivity is associated with a greater incidence of recurrence and/or metastasis. There was no association between overexpression of MPS-1 and poor Overall Survival (OS) (p=0.146). The results presented here indicate a significant correlation between overexpression of MPS-1/S27 ribosomal protein and more aggressive breast cancer growth. These results suggest that the MPS-1 antigen may be a useful marker to understand better the biological behavior of breast cancer.
金属全刺激素（MPS-1）/S27核糖体蛋白参与细胞增殖和肿瘤发生。在本研究中，我们检测了120例I期和II期乳腺癌中MPS-1蛋白的表达，以研究其与乳腺癌预后的关系。我们还确定了MPS-1与其他常用于乳腺癌预后的生物学标志物之间是否存在关联。使用特异性抗MPS-1抗体通过免疫组织化学分析MPS-1蛋白的表达。我们发现，在更大尺寸和更高组织学分级的肿瘤中MPS-1表达更高。因此，在具有更高组织学侵袭性的肿瘤中MPS-1更多。两者都经常与更高的增殖活性相关。MPS-1的表达与孕激素受体（p=0.004）、雌激素受体（p=0.03）、bcl-2（p=0.002）和MIB-1（p=0.03）的表达之间也存在显著关联。单因素逻辑回归分析后，我们发现MPS-1的过表达与无病生存期（DFS）相关（p=0.039），表明MPS-1阳性与更高的复发和/或转移发生率相关。MPS-1的过表达与较差的总生存期（OS）之间无关联（p=0.146）。此处呈现的结果表明MPS-1/S27核糖体蛋白的过表达与更具侵袭性的乳腺癌生长之间存在显著相关性。这些结果表明，MPS-1抗原可能是更好地了解乳腺癌生物学行为的有用标志物。
