Recent developments in the use of nitrates for treatment of angina pectoris.
作者信息
Ankier S I, Warrington S J, Sneddon J M
机构信息
Charterhouse Clinical Research Unit Ltd., London, UK.
出版信息
J Int Med Res. 1988 Jul-Aug;16(4):249-56. doi: 10.1177/030006058801600401.
PMID:3139481
Abstract
Organic nitrates are effective in the treatment and prophylaxis of angina pectoris. The major clinical problem of tolerance may be avoided if the daily plasma concentrations of the active metabolite, isosorbide-5-mononitrate are maintained at 100-300 ng/ml. The most promising development in achieving this is the use of sustained release preparations.
摘要
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