Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA.
Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Infect Dis Clin North Am. 2019 Sep;33(3):857-868. doi: 10.1016/j.idc.2019.04.007.
The Berlin patient, a famous example for human immunodeficiency virus (HIV) cure, had received a bone marrow transplantation with an HIV resistance mutation. The authors describe his case and others that had shown HIV control, like the Mississippi baby who was started on antiretroviral therapy very early after birth, and posttreatment controllers, like the VISCONTI cohort. Moreover, the authors outline various strategies, oftentimes informed by these individuals, that have been tried in vitro, in animal models, or in human trials, to deplete the latent reservoir, which is considered the basis of HIV persistence and the obstacle to cure.
柏林病人是人类免疫缺陷病毒 (HIV) 治愈的著名范例，他接受了带有 HIV 耐药突变的骨髓移植。作者描述了他的病例和其他一些 HIV 得到控制的病例，如密西西比婴儿，他在出生后非常早期就开始接受抗逆转录病毒治疗，以及治疗后控制者，如 VISCONTI 队列。此外，作者概述了各种策略，这些策略通常是基于这些个体的信息，已经在体外、动物模型或人体试验中尝试过，以耗尽潜伏库，这被认为是 HIV 持续存在和治愈障碍的基础。
