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密闭化学-生物化学体系作为一种生化递药平台。

A Closed Chemobrionic System as a Biochemical Delivery Platform.

机构信息

Department of Pharmacognosy-Pharmacology, School of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, 54124, Greece.

出版信息

Chemistry. 2019 Oct 8;25(56):12916-12919. doi: 10.1002/chem.201903255. Epub 2019 Sep 10.

Abstract

Inorganic cells bearing calcium silicate membranes were prepared and resembled closed chemical gardens. It was demonstrated that these inorganic cells can successfully be loaded with natural products, proteins and plasmid DNA, and their cargo can be released in a controlled manner. These cells demonstrated the ability of chemical gardens to act as platforms for the sustained delivery of biomolecules and are expected to introduce chemical gardens in the field of biosciences.

摘要

制备了具有硅酸钙膜的无机细胞,这些细胞类似于封闭的化学花园。结果表明,这些无机细胞可以成功负载天然产物、蛋白质和质粒 DNA,并且可以以可控的方式释放其货物。这些细胞证明了化学花园作为生物分子持续输送平台的能力,有望将化学花园引入生物科学领域。

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