State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences , Guangxi Normal University , Guilin 541004 , China.
Anal Chem. 2019 Sep 3;91(17):11455-11460. doi: 10.1021/acs.analchem.9b02938. Epub 2019 Aug 20.
A hydrothermal strategy for preparing boron and nitrogen codoped carbon quantum dots was studied using the precursors of -amino salicylic acid, boric acid and ethylene glycol dimethacrylate. The boron and nitrogen codoped carbon quantum dots have high fluorescence intensity, good monodispersity, high stability, superior water solubility, and a fluorescence quantum yield of 19.6%. Their average size is 5 nm. Their maximum excitation and emission wavelengths are 380 and 520 nm, respectively. Permanganate (MnO) quenched boron and nitrogen codoped carbon quantum dots fluorescence through inner filter effect and static quenching effects. The linear relation between quenching efficiency and MnO concentration ranged from 0.05 to 60 μmol/L with a detection limit of 13 nmol/L. In the presence of captopril, MnO was reduced to Mn and the fluorescence of boron and nitrogen codoped carbon quantum dots was recovered. The linear range between recovery and captopril concentration was from 0.1 to 60 μmol/L. The limit of detection was 0.03 μmol/L. The developed method can be employed as a sensitive fluorescence sensing platform for MnO. It has been successfully used for captopril detection in mouse plasma.
采用 -氨基水杨酸、硼酸和乙二醇二甲基丙烯酸酯作为前驱体，研究了一种水热法制备硼氮共掺杂碳量子点的方法。所制备的硼氮共掺杂碳量子点具有较高的荧光强度、良好的单分散性、较高的稳定性、优异的水溶性和 19.6%的荧光量子产率。其平均粒径为 5nm，最大激发和发射波长分别为 380nm 和 520nm。高锰酸盐（MnO）通过内滤效应和静态猝灭效应猝灭硼氮共掺杂碳量子点的荧光。猝灭效率与 MnO 浓度在 0.05-60μmol/L 范围内呈线性关系，检测限为 13nmol/L。在卡托普利存在下，MnO 被还原为 Mn，硼氮共掺杂碳量子点的荧光得到恢复。恢复与卡托普利浓度之间的线性范围为 0.1-60μmol/L，检测限为 0.03μmol/L。该方法可作为一种灵敏的荧光传感平台用于 MnO 的检测，并已成功用于小鼠血浆中卡托普利的检测。
