Key Laboratory of Drug-Targeting & Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drugs & Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, PR China.
Nanomedicine (Lond). 2019 Aug;14(16):2169-2187. doi: 10.2217/nnm-2019-0110. Epub 2019 Aug 9.
We aimed to construct human serum albumin-Kolliphor HS 15 nanoparticles (HSA-HS15 NPs) to overcome the limitations in targeted therapy for rheumatoid arthritis (RA) and enhance the safety of drug-loaded HSA NPs. Celastrol (CLT)-loaded HSA-HS15 NPs were prepared and the properties were adequately investigated; the treatment effect were evaluated in RA rats; and studies were performed to explain the mechanism. CLT-HSA-HS15 NPs had remarkable treatment ability and enhanced safety in the treatment of RA compared with free CLT and CLT-HSA NPs. HSA-HS15 NPs could be a safe and efficient therapeutic strategy for the treatment of RA, because of the inflammatory targeting ability of albumin, the added HS15 and ELVIS effect (extravasation through leaky vasculature followed by inflammatory cell-mediated sequestration) of nanoparticles.
我们旨在构建人血清白蛋白 - 聚氧乙烯氢化蓖麻油 15 纳米粒（HSA-HS15 NPs），以克服类风湿关节炎（RA）靶向治疗的局限性，并提高载药 HSA NPs 的安全性。载姜黄素（CLT）的 HSA-HS15 NPs 被制备并充分研究了其性质；在 RA 大鼠中评估了治疗效果；并进行了研究以解释机制。与游离 CLT 和 CLT-HSA NPs 相比，CLT-HSA-HS15 NPs 在治疗 RA 方面具有显著的治疗能力和增强的安全性。由于白蛋白的炎症靶向能力、纳米粒的 HS15 和 ELVIS 效应（通过渗漏的血管外渗，随后被炎症细胞介导的隔离），HSA-HS15 NPs 可能成为治疗 RA 的一种安全有效的治疗策略。
