Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, USA.
Department of Dairy Science, University of Wisconsin-Madison, Madison, WI, USA.
J Dev Orig Health Dis. 2020 Feb;11(1):71-77. doi: 10.1017/S2040174419000424. Epub 2019 Aug 9.
Although bariatric surgery is approved for a woman of child-bearing age with an interest in subsequent pregnancy, reports of in utero growth issues during pregnancy have garnered a closer look at the impact of maternal surgical weight loss on the pre- and postpartum periods. Offspring of dams having received vertical sleeve gastrectomy (VSG) are born small-for-gestational age and have increased risk for metabolic syndrome later in life. Here, we aimed to determine whether the postnatal catch-up growth trajectory of bariatric offspring may be affected by milk composition. Milk samples were collected at postnatal day 15/16 from dams having received VSG surgery and fed a high-fat diet (HFD) (H-VSG), Sham surgery and fed chow (C-Sham), or Sham surgery and fed HFD (H-Sham). Milk obtained from H-VSG dams had elevated glucose (P < 0.05) and significantly reduced triglyceride content (P < 0.01). Milk from H-Sham dams had the lowest amount of milk protein (P < 0.05). Fatty acid composition measured by fractionation was largely not affected by surgery but rather maternal diet. No difference was observed in milk leptin levels; however, insulin, adiponectin, and growth hormone levels were significantly increased in milk from H-VSG animals. H-Sham had the lowest level of immunoglobulin (Ig)A, whereas IgG was significantly reduced in H-VSG. Taken together, the quality of milk from H-VSG dams suggests that milk composition could be a factor in reducing the rate of growth during the lactation period.
尽管减重手术已被批准用于有生育意向的育龄妇女，但妊娠期间胎儿宫内生长问题的报告促使人们更密切地关注母亲手术减肥对产前和产后期间的影响。接受垂直袖状胃切除术 (VSG) 的母鼠所生的后代出生时为小于胎龄儿，并且在以后的生活中患代谢综合征的风险增加。在这里，我们旨在确定减重后代的产后追赶生长轨迹是否可能受到乳汁成分的影响。在产后第 15/16 天，从接受 VSG 手术并喂食高脂肪饮食 (HFD) 的母鼠 (H-VSG)、接受假手术并喂食标准饮食的母鼠 (C-Sham) 或接受假手术并喂食 HFD 的母鼠 (H-Sham) 中收集乳汁样本。来自 H-VSG 母鼠的乳汁中葡萄糖含量升高（P < 0.05），甘油三酯含量显著降低（P < 0.01）。来自 H-Sham 母鼠的乳汁中蛋白质含量最低（P < 0.05）。通过分级测量的脂肪酸组成受手术影响不大，但受母体饮食影响较大。乳汁瘦素水平没有差异；然而，来自 H-VSG 动物的乳汁中胰岛素、脂联素和生长激素水平显著升高。H-Sham 的免疫球蛋白 (Ig)A 水平最低，而 H-VSG 的 IgG 显著降低。总之，H-VSG 母鼠乳汁的质量表明，乳汁成分可能是降低哺乳期生长速度的一个因素。
