Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA.
Sci Transl Med. 2013 Aug 21;5(199):199ra112. doi: 10.1126/scitranslmed.3006505.
Obesity has profound negative consequences on female reproduction as well as on the metabolic health of offspring. Bariatric surgery is the most effective method for sustained weight loss. A critical question is whether bariatric surgery can reverse the deleterious effects of obesity on both female reproduction and subsequent offspring. Vertical sleeve gastrectomy (VSG) is a bariatric procedure rapidly growing in popularity because it provides weight loss and other metabolic benefits that are comparable to those offered by the more complicated Roux-en-Y gastric bypass (RYGB). Female rats rendered obese on a high-fat diet (HFD) underwent either VSG or sham surgery. Like their male counterparts, females had significant metabolic improvements including reduced adiposity and improved glucose tolerance. After VSG, female rats showed a more normal reproductive cycle. Despite these maternal benefits, the offspring of dams receiving VSG were born smaller and lighter than offspring of control dams that underwent sham surgery. When maintained on an HFD after puberty, these adult offspring had a greater propensity to develop glucose intolerance and increased adiposity than the offspring of lean mothers or obese mothers who underwent sham surgery. These data suggest that weight loss alone by obese mothers is not sufficient to reverse the deleterious effects of an HFD and obesity on their offspring.
肥胖对女性生殖和后代的代谢健康有深远的负面影响。减重手术是持续减肥最有效的方法。一个关键问题是减重手术是否可以逆转肥胖对女性生殖和后代的有害影响。垂直袖状胃切除术（VSG）是一种越来越受欢迎的减重手术，因为它提供了与更复杂的 Roux-en-Y 胃旁路术（RYGB）相当的减肥和其他代谢益处。高脂肪饮食（HFD）诱导肥胖的雌性大鼠接受 VSG 或假手术。与雄性大鼠一样，雌性大鼠的代谢也有显著改善，包括体脂减少和葡萄糖耐量改善。VSG 后，雌性大鼠的生殖周期更正常。尽管有这些母体益处，但接受 VSG 的母鼠的后代比接受假手术的对照母鼠的后代出生时更小、更轻。青春期后，这些成年后代在高脂肪饮食下更容易出现葡萄糖不耐受和肥胖，而瘦母鼠或肥胖母鼠的后代则没有。这些数据表明，肥胖母亲仅通过减肥不足以逆转 HFD 和肥胖对其后代的有害影响。
