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基于二硒化钨-半胱氨酸-多巴胺纳米探针与带有超低背景噪声的错配催化发夹组装目标循环的光电化学检测 miRNA-221 的设计。

A design for the photoelectrochemical detection of miRNA-221 based on a tungsten diselenide-cysteine-dopamine nanoprobe coupled with mismatched catalytic hairpin assembly target recycling with ultra-low background noise.

机构信息

Key Laboratory of Optic-Electric Sensing and Analytical Chemistry for Life Science, MOE, Shandong Key Laboratory of Biochemical Analysis, Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China.

出版信息

Chem Commun (Camb). 2019 Aug 27;55(70):10380-10383. doi: 10.1039/c9cc05625d.

DOI:10.1039/c9cc05625d
PMID:31397448
Abstract

A strategy for the photoelectrochemical detection of miRNA with ultra-low background noise was developed using tungsten diselenide-cysteine-dopamine (WSe2/Cys/DA) as a nanoprobe coupled with mismatched catalytic hairpin assembly target recycling. A superior detection limit of 3.3 aM toward miRNA-221 was achieved.

摘要

开发了一种使用二硒化钨-半胱氨酸-多巴胺 (WSe2/Cys/DA) 作为纳米探针与错配催化发夹组装靶标循环相结合的光电化学检测 miRNA 的策略。该策略对 miRNA-221 的检测限达到 3.3 aM。

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