Björlin G, Nilsson I M
Department of Oral Surgery, University of Lund, Malmö General Hospital, Sweden.
Int J Oral Maxillofac Surg. 1988 Aug;17(4):275-6. doi: 10.1016/s0901-5027(88)80056-0.
The effect on the tensile strength of healing wounds of 2 of the most commonly used antifibrinolytic substances, tranexamic acid and epsilon-aminocaproic acid, has been studied in white rats. 2 symmetrical linear lines were made on the dorsal skin, in 1 of which was injected 1 ml of the test solution. The incisions were closed with interrupted sutures, and after 7 days the animal was sacrificed, the wound excised and its tensile strength determined. The results showed tranexamic acid (1 ml of a solution containing 100 mg/ml) to have a positive effect on wound healing, whereas epsilon-aminocaproic acid (1 ml of a solution containing 400 mg/ml) had a negative effect. When both agents were compared in the same animal, wounds in tissue injected with tranexamic acid had a higher tensile strength than those made in tissue pre-treated with epsilon-aminocaproic acid. Even compared at the same ionic strength, similar results were obtained. It is clear from this investigation that, unlike epsilon-aminocaproic acid, tranexamic acid has a positive effect on wound healing, and that this effect is not due to the antifibrinolytic properties, as both are powerful fibrinolytic inhibitors.
在白鼠身上研究了两种最常用的抗纤维蛋白溶解物质——氨甲环酸和ε-氨基己酸对愈合伤口抗张强度的影响。在背部皮肤制造两条对称的线性切口，其中一处注射1毫升测试溶液。切口用间断缝合关闭，7天后处死动物，切除伤口并测定其抗张强度。结果显示，氨甲环酸（1毫升含100毫克/毫升的溶液）对伤口愈合有积极作用，而ε-氨基己酸（1毫升含400毫克/毫升的溶液）有消极作用。当在同一只动物身上比较这两种药剂时，注射氨甲环酸的组织中的伤口比用ε-氨基己酸预处理的组织中的伤口具有更高的抗张强度。即使在相同离子强度下进行比较，也得到了类似结果。从这项研究可以清楚地看出，与ε-氨基己酸不同，氨甲环酸对伤口愈合有积极作用，而且这种作用并非归因于抗纤维蛋白溶解特性，因为二者都是强大的纤维蛋白溶解抑制剂。
