Yoo J K, Murakami M, Teramura S, Saita H, Kusaka S, Matsuo K, Kita T, Miyake T
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
Scand J Gastroenterol Suppl. 1989;162:215-7. doi: 10.3109/00365528909091164.
We examined the protective effect of plasmin inhibitors on gastric mucosal vascular permeability in rats. Tranexamic acid and aminocaproic acid significantly inhibited the increase in vascular permeability and macroscopic gastric mucosal lesions induced by 50% ethanol and 1% ammonia. The protective effect afforded by plasmin inhibitors was not affected by pretreatment with indomethacin. Our results show that plasmin inhibitors inhibit the increase in gastric vascular permeability and suggest that plasmin may play an important role in the pathogenesis of gastric mucosal damage.
我们研究了纤溶酶抑制剂对大鼠胃黏膜血管通透性的保护作用。氨甲环酸和氨基己酸显著抑制了50%乙醇和1%氨水诱导的血管通透性增加及胃黏膜肉眼可见的损伤。纤溶酶抑制剂所提供的保护作用不受吲哚美辛预处理的影响。我们的结果表明，纤溶酶抑制剂可抑制胃血管通透性的增加，并提示纤溶酶可能在胃黏膜损伤的发病机制中起重要作用。
