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醋氨己酸锌与醋氨己酸钠对兔皮肤伤口愈合抗炎活性的比较

Comparison of the anti-inflammatory activity of sodium acexamate and zinc acexamate in healing skin wounds in rabbits.

作者信息

Guillard O, Masson P, Piriou A, Brugier J C, Courtois P

出版信息

Pharmacology. 1987;34(5):296-300. doi: 10.1159/000138282.

DOI:10.1159/000138282
PMID:3615571
Abstract

After obtaining an abscess on the inner thigh of rabbits, the resulting inflammatory area was treated with sodium acexamate and zinc acexamate (0.5 ml s.c. of a 7% w/v solution). All animals received labeled leukocytes (111In, 1 mCi, i.v.). The hyperfixation was measured by comparing the inflammatory areas. In the group treated with zinc acexamate, the regression of inflammation was highly significant (p less than 0.001) in comparison with the other groups. These results emphasize the importance of combining zinc with acexamic acid for healing skin wounds.

摘要

在兔大腿内侧形成脓肿后,用醋氨己酸锌(0.5毫升皮下注射7% w/v溶液)治疗由此产生的炎症区域。所有动物均静脉注射标记白细胞(铟-111,1毫居里)。通过比较炎症区域来测量高摄取率。与其他组相比,用醋氨己酸锌治疗的组炎症消退非常显著(p < 0.001)。这些结果强调了锌与醋氨己酸联合用于愈合皮肤伤口的重要性。

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Comparison of the anti-inflammatory activity of sodium acexamate and zinc acexamate in healing skin wounds in rabbits.醋氨己酸锌与醋氨己酸钠对兔皮肤伤口愈合抗炎活性的比较
Pharmacology. 1987;34(5):296-300. doi: 10.1159/000138282.
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