Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China.
Kanion Pharmaceutical Co. Ltd., State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China.
Fitoterapia. 2019 Oct;138:104290. doi: 10.1016/j.fitote.2019.104290. Epub 2019 Aug 6.
Six new monoterpene glycosides, named 6'-O-nicotinoylalbiflorin (1), 4'-O-vanillylalbiflorin (2), paeonidanin L (3), paeoniflorigenin-1-O-β-d-xyloside (4), 6'-(2-hydroxypropanoyl)-paeoniflorin (5), oxylactiflorin (6), together with 16known ones (7-22) were isolated from the 70% ethanol extract of Paeoniae Radix. Their structures were elucidated based on spectroscopic analysis (1D and 2D NMR, HRESIMS, IR and UV), chemical evidences and comparison with literatures. The inhibitory effects of all the isolates were evaluated against lipopolysaccharide (LPS) stimulated PGE production in RAW 264.7 macrophages.
从白芍的 70%乙醇提取物中分离得到了 6 个新的单萜糖苷，分别命名为 6'-O-烟酰基白芍苷（1）、4'-O-香草酰基白芍苷（2）、牡丹苷 L（3）、芍药苷-1-O-β-d-木糖苷（4）、6'-(2-羟基丙酰基）-白芍苷（5）、氧化芍药苷（6），以及 16 个已知化合物（7-22）。基于光谱分析（1D 和 2D NMR、HRESIMS、IR 和 UV）、化学证据和与文献的比较，确定了它们的结构。所有分离物均对 RAW 264.7 巨噬细胞中脂多糖（LPS）刺激的 PGE 产生的抑制作用进行了评估。
