State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China.
Acta Biomater. 2019 Oct 1;97:597-607. doi: 10.1016/j.actbio.2019.08.009. Epub 2019 Aug 6.
An effective treatment for peri-implantitis is to completely remove all the bacterial deposits from the contaminated implants, especially the organic residues, to regain biocompatibility and re-osseointegration, but none of the conventional decontamination treatments has achieve this goal. The photocatalytic activity of TiO coating on titanium implants to degrade organic contaminants has attracted researchers' attention recently. But a pure TiO coating only responses to harmful ultraviolet light. Additionally, the poor coating mechanical properties are unable to protect the coating integrity versus initial mechanical decontamination. To address these issues, a unique TiO nanoceramic coating was fabricated on titanium substrates through an innovative plasma electrolytic oxidation (PEO) based procedure, which showed a disordered layer with oxygen vacancies on the outmost part. As a result, the coating could decompose methylene blue, rhodamine B, and pre-adsorbed lipopolysaccharide (LPS) under visible light. Additionally, the coating showed two-fold higher hardness than untreated titanium and excellent wear resistance against steel decontamination instruments, which could be attributed to the specific micro-structure, including the densely packed nanocrystals and good metallurgical combination. Moreover, the in vitro response of MG63 cells confirmed that the coating had comparable biocompatibility and osteoconductivity to untreated titanium substrates. This study provides a unique coating technique as well as a photocatalytic cleaning strategy to enhance decontamination of titanium dental implants, which will favour the development of peri-implantitis treatments. STATEMENT OF SIGNIFICANCE: The treatment of peri-implantitis is based on the complete removal of bacterial deposits, especially the organic residues, but conventional decontamination treatments are hard to achieve it. The photocatalytic activity of TiO coating on titanium implants to degrade organic contaminants provides a promising strategy for deeper decontamination, but its nonactivation to visible light and poor mechanical properties have limited its application. To address these issues, a unique TiO nanoceramic coating was fabricated on titanium substrates based on plasma electrolytic oxidation. The coating showed enhanced visible-light photocatalytic activity, excellent wear resistance and satisfied biocompatibility. Based on this functional coating, it is promising to develop a more efficient strategy for deep decontamination of implant surface, which will favour the development of peri-implantitis treatments.
一种有效的治疗种植体周围炎的方法是彻底清除受污染种植体上的所有细菌沉积物，尤其是有机残留物，以恢复生物相容性和再骨整合，但目前没有一种常规的去污处理方法能够达到这一目标。最近，研究人员关注到钛种植体上 TiO 涂层的光催化活性，以降解有机污染物。但纯 TiO 涂层只能响应有害的紫外线。此外，较差的涂层机械性能无法保护涂层完整性以抵抗初始机械去污。为了解决这些问题，通过一种创新的基于等离子体电解氧化（PEO）的工艺，在钛基体上制备了一种独特的 TiO 纳米陶瓷涂层，该涂层在最外层显示出具有氧空位的无序层。结果表明，该涂层可以在可见光下分解亚甲基蓝、罗丹明 B 和预吸附的脂多糖（LPS）。此外，与未经处理的钛相比，该涂层的硬度提高了两倍，对钢去污器械的耐磨性也很好，这归因于其独特的微观结构，包括密集堆积的纳米晶体和良好的冶金结合。此外，体外 MG63 细胞反应证实，该涂层具有与未经处理的钛基底相当的生物相容性和骨诱导性。本研究提供了一种独特的涂层技术和光催化清洁策略，以增强钛牙种植体的去污效果，这将有利于种植体周围炎治疗的发展。
种植体周围炎的治疗基于彻底清除细菌沉积物，尤其是有机残留物，但常规的去污处理很难达到这一目标。钛种植体上 TiO 涂层的光催化活性降解有机污染物为更深入的去污提供了一种有前途的策略，但由于其对可见光的非激活和较差的机械性能，限制了其应用。为了解决这些问题，我们在钛基体上基于等离子体电解氧化制备了一种独特的 TiO 纳米陶瓷涂层。该涂层表现出增强的可见光光催化活性、优异的耐磨性和令人满意的生物相容性。基于这种功能性涂层，有望开发出更有效的种植体表面深度去污策略，这将有利于种植体周围炎治疗的发展。
