Allen C M, Rossie K M, Haring J I, Beck F M
Ohio State University, College of Dentistry, Columbus 43210.
J Oral Pathol. 1988 Apr;17(4):158-63. doi: 10.1111/j.1600-0714.1988.tb01517.x.
The purpose of this study was to determine whether the mucosal alterations of the dorsal rat tongue produced by Candida albicans infection were reversible upon treatment with the antifungal drug ketoconazole. Following experimentally-produced infection, 17 rats showed clinical evidence of persistent lesions over a period of 20 weeks. Eight of these animals were then treated with ketoconazole daily for 2 weeks (20 mg/kg/day). Appropriate non-infected controls and ketoconazole-only controls were also maintained. Five weeks after the ketoconazole treatment, all animals were killed and the dorsal tongues evaluated clinically and histologically. Control groups showed no abnormalities. Of the 8 animals in the treated-lesion group, all showed lesional resolution, while only 2 of the 9 animals in the untreated-lesion group showed resolution of their lesions (p = 0.002). These findings indicate that the epithelial changes produced by this candidal isolate for this period of time are reversible.
本研究的目的是确定白色念珠菌感染所致大鼠舌背黏膜改变在用抗真菌药物酮康唑治疗后是否可逆。在实验性感染后，17只大鼠在20周的时间里出现了持续性病变的临床证据。其中8只动物随后每天接受酮康唑治疗2周（20毫克/千克/天）。还设立了适当的未感染对照组和仅使用酮康唑的对照组。酮康唑治疗5周后，所有动物均被处死，并对舌背进行临床和组织学评估。对照组未显示异常。在治疗病变组的8只动物中，所有动物的病变均得到消退，而在未治疗病变组的9只动物中，只有2只动物的病变得到消退（p = 0.002）。这些发现表明，在此时间段内该念珠菌分离株所引起的上皮变化是可逆的。
