Bruatto M, Marinuzzi G, Raiteri R, Sinicco A
Istituto di Malattie Infettive dell'Università di Torino, Italy.
Mycoses. 1992 Jan-Feb;35(1-2):53-6. doi: 10.1111/j.1439-0507.1992.tb00819.x.
The MIC values of the antifungal drug ketoconazole were evaluated on 66 Candida albicans strains. These strains were isolated from 26 HIV-1 infected patients with oral recurrent candidosis. Each episode of oral candidosis observed in these patients was orally treated with ketoconazole (200 mg/day) until the clinical disappearance of the lesions. The most frequent MIC values were 20 micrograms/ml and 10 micrograms/ml, observed in 37 and 19 isolates respectively. Only strains from five patients showed changes in their susceptibility to ketoconazole. This fact could indicate that a different strain causes the subsequent reappearance of the oral lesions, rather than the drug selecting resistant fungal strains. Our results stress the role of host characteristics in the occurrence of candidal infections, pointing to the progressing failure of the immunological response as the most important factor responsible for the recurrence of oral candidosis during HIV-1 infection.
对66株白色念珠菌菌株评估了抗真菌药物酮康唑的最低抑菌浓度（MIC）值。这些菌株分离自26例患有复发性口腔念珠菌病的HIV-1感染患者。在这些患者中观察到的每一次口腔念珠菌病发作均口服酮康唑（200毫克/天），直至病变临床消失。最常见的MIC值分别为20微克/毫升和10微克/毫升，分别在37株和19株分离菌株中观察到。只有5例患者的菌株对酮康唑的敏感性出现了变化。这一事实可能表明，导致口腔病变随后再次出现的是不同的菌株，而非药物选择出了耐药真菌菌株。我们的结果强调了宿主特征在念珠菌感染发生中的作用，指出免疫反应逐渐失效是HIV-1感染期间口腔念珠菌病复发的最重要因素。
