Martins Laís Bhering, Rodrigues Ana Maria Dos Santos, Monteze Nayara Mussi, Tibaes Jenneffer Rayane Braga, Amaral Matheus Henrique Alves, Gomez Rodrigo Santiago, Teixeira Antônio Lúcio, Ferreira Adaliene Versiani Matos
Department of Nutrition, Nursing School, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Cephalalgia. 2020 Jan;40(1):88-95. doi: 10.1177/0333102419869319. Epub 2019 Aug 9.
Previous studies have shown an analgesic effect of ginger in the acute treatment of migraine, and there is anecdotal evidence of its efficacy in migraine prophylaxis.
This study aimed to evaluate the potential of ginger to prevent migraine attacks.
This double-blind, placebo-controlled randomized clinical trial took place at the Headache Clinic, Universidade Federal de Minas Gerais (Belo Horizonte, Minas Gerais, Brazil), involving 107 patients. Only subjects diagnosed with episodic migraine, aged between 18 and 60 years old, and who were not taking any prophylactic medication, were enrolled in the study. After one month of observation, subjects selected for the study were randomized 1:1 into placebo and treatment groups. Patients received capsules three times per day of 200 mg of dry extract of ginger (5% active ingredient) or placebo (cellulose) for three months. Visits were performed monthly and the patients were asked to fill in a migraine diary. The adherence to treatment was evaluated by counting capsules.
The percentage of patients who responded to treatment (i.e. a reduction of 50% in the number of migraine attacks at the end of treatment) did not differ between the groups. There was a decrease in the number of days with severe pain, analgesic use for acute migraine and duration of migraine attacks in both groups, without significant difference between ginger and placebo groups.
Ginger provides no greater benefit in the prophylactic treatment of migraine when compared to placebo. This trial is registered at ClinicalTrials.gov (NCT02570633).
先前的研究表明，生姜在偏头痛的急性治疗中具有镇痛作用，并且有轶事证据表明其在偏头痛预防中有效。
本研究旨在评估生姜预防偏头痛发作的潜力。
这项双盲、安慰剂对照的随机临床试验在米纳斯吉拉斯联邦大学头痛诊所（巴西米纳斯吉拉斯州贝洛奥里藏特）进行，涉及107名患者。只有被诊断为发作性偏头痛、年龄在18至60岁之间且未服用任何预防性药物的受试者被纳入研究。经过一个月的观察后，入选研究的受试者按1:1随机分为安慰剂组和治疗组。患者每天服用三次胶囊，其中生姜干提取物（活性成分5%）200毫克或安慰剂（纤维素），持续三个月。每月进行随访，并要求患者填写偏头痛日记。通过计算胶囊数量评估治疗依从性。
两组中对治疗有反应的患者百分比（即治疗结束时偏头痛发作次数减少50%）没有差异。两组中严重疼痛天数、急性偏头痛的镇痛药物使用情况以及偏头痛发作持续时间均有所减少，生姜组和安慰剂组之间无显著差异。
与安慰剂相比，生姜在偏头痛的预防性治疗中没有更大的益处。该试验已在ClinicalTrials.gov注册（NCT02570633）。
