Varshney Mohit, Dhingra Kriti, Choudhury Ashok
Department of Psychiatry, ILBS Hospital, Vasant Kunj, New Delhi, 110070, India.
Department of Hepatology, ILBS Hospital, Vasant Kunj, New Delhi, 110070, India.
J Clin Exp Hepatol. 2024 Jan-Feb;14(1):101261. doi: 10.1016/j.jceh.2023.07.414. Epub 2023 Jul 28.
Liver transplant cases have been rising and becoming the choice of treatment for many patients with end-stage liver diseases. With an increasing number of qualified treatment centers and facilities, the effectiveness of liver transplants has been observed to increase over the years. But the success of liver transplants and the quality of life post-transplant have been observed to be influenced due to psychiatric comorbidities.
We searched for literature using terms for 'Psychosocial factors', 'liver transplant', 'psychiatric disorders', 'treatment outcomes', and related terms, 'AUD/SUD' in three databases: PubMed, Embase, and Scopus. Articles published in English and that provided original data analyses were included while commentaries and review articles were excluded. This review article focuses on an association between various psychiatric disorders/ Substance Use Disorder (SUD)/Alcohol Use Disorder (AUD) and liver transplant outcomes which indicated the need for psychiatric treatment and its role in improved overall transplant outcomes and enhanced quality of life.
Majority of the studies indicated a negative association between psychiatric disorder, AUD, and SUD with the treatment outcomes post liver transplant. A few studies were found supporting a multidisciplinary approach to handling liver transplant patients for a more effective and improved treatment outcome.
The current evidence suggests a need for developing an integrated approach to assessment and management of psychiatric and psychosocial issues related to liver transplant recipients.
肝移植病例一直在增加,已成为许多终末期肝病患者的治疗选择。随着合格治疗中心和设施数量的增加,多年来肝移植的有效性已有所提高。但据观察,肝移植的成功率和移植后的生活质量会受到精神疾病合并症的影响。
我们在三个数据库(PubMed、Embase和Scopus)中使用“心理社会因素”“肝移植”“精神疾病”“治疗结果”以及相关术语“AUD/SUD”进行文献检索。纳入以英文发表且提供原始数据分析的文章,排除评论文章和综述文章。这篇综述文章重点关注各种精神疾病/物质使用障碍(SUD)/酒精使用障碍(AUD)与肝移植结果之间的关联,这表明需要进行精神治疗及其在改善整体移植结果和提高生活质量方面的作用。
大多数研究表明,精神疾病、AUD和SUD与肝移植后的治疗结果呈负相关。发现有少数研究支持采用多学科方法来处理肝移植患者,以获得更有效和更好的治疗结果。
目前的证据表明,需要制定一种综合方法来评估和管理与肝移植受者相关的精神和心理社会问题。