Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University of Medical Science, Chongqing, China.
Adv Exp Med Biol. 2019;1165:525-541. doi: 10.1007/978-981-13-8871-2_26.
Since the lipid nephrotoxicity hypothesis was proposed in 1982, increasing evidence has supported the hypothesis that lipid abnormalities contributed to the progression of glomerulosclerosis. In this chapter, we will discuss the general promises of the original hypothesis, focusing especially on the role of lipids and metabolic inflammation accompanying CKD in renal fibrosis and potential new strategies of prevention.
自 1982 年提出脂质肾毒性假说以来，越来越多的证据支持了脂质异常导致肾小球硬化进展的假说。在本章中，我们将讨论原始假说的普遍意义，特别是脂质和 CKD 伴随的代谢炎症在肾脏纤维化中的作用以及潜在的新预防策略。
