School of Health Sciences, Oral Medicine Division, Pontifical Catholic University of Rio Grande do Sul-PUCRS, Porto Alegre, Brazil.
J Clin Pharm Ther. 2019 Dec;44(6):838-843. doi: 10.1111/jcpt.13022. Epub 2019 Aug 10.
In addition to its antimicrobial effect, doxycycline has potent anti-inflammatory activity. In view of these pharmacological characteristics, its use in the management of inflammatory, autoimmune and granulomatous diseases has been proposed. The objective of this study was to investigate, through a systematic literature review, the effect of doxycycline on pain and healing of ulcerated lesions of the mouth.
An electronic search was performed in accordance with PRISMA guidelines in PubMed, Cochrane Central Register, Web of Science, Bireme/LILACS and Scopus databases. Controlled, randomized clinical trials were selected. The concentration of doxycycline, frequency of application, pain relief and clinical remission of the lesions were analysed.
According to the inclusion criteria, five articles were selected. In four of these studies, doxycycline was used in the treatment of aphthous stomatitis, and in one study, it was used in the treatment of herpes labialis. In all studies, the drug was used topically, both as a hydrogel and as a crushed tablet (along with a prosthetic adhesive). The groups treated with doxycycline showed faster healing of lesions and lower pain scores compared to placebo.
The present study suggests that topical doxycycline has a positive effect on the treatment of recurrent aphthous ulceration and herpes labialis. Experimental animal studies and double-blind randomized clinical trials should be performed on other oral lesions, such as traumatic ulcers and mucositis.
除了其抗菌作用外，强力霉素还具有很强的抗炎活性。鉴于这些药理特性，已经提出将其用于治疗炎症、自身免疫和肉芽肿性疾病。本研究的目的是通过系统文献回顾，调查强力霉素对口腔溃疡性病变疼痛和愈合的影响。
根据 PRISMA 指南，在 PubMed、Cochrane 中央注册处、Web of Science、Bireme/LILACS 和 Scopus 数据库中进行电子检索。选择对照、随机临床试验。分析了强力霉素的浓度、应用频率、疼痛缓解和病变的临床缓解。
根据纳入标准，选择了 5 篇文章。其中 4 项研究将强力霉素用于治疗阿弗他口炎，1 项研究将其用于治疗唇疱疹。在所有研究中，药物均局部使用，既有凝胶形式也有压碎片剂（与义齿胶粘剂一起）。与安慰剂相比，使用强力霉素的组的病变愈合更快，疼痛评分更低。
本研究表明，局部使用强力霉素对复发性阿弗他溃疡和唇疱疹的治疗有积极影响。应该对其他口腔病变，如创伤性溃疡和黏膜炎，进行动物实验研究和双盲随机临床试验。
