局部应用盐酸多西环素单次治疗复发性阿弗他口腔溃疡。
Single application of topical doxycycline hyclate in the management of recurrent aphthous stomatitis.
机构信息
Assistant Professor, Department of Dentistry, ESIC Medical College & PGIMSR, KK Nagar, Chennai, Tamilnadu, India.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Oct;116(4):440-6. doi: 10.1016/j.oooo.2013.06.015.
OBJECTIVE
Although tetracyclines are used for topical therapy in recurrent aphthous stomatitis (RAS) patients, there are few clinical trials that have used doxycycline. Hence, we evaluated the therapeutic efficacy of topical doxycycline hyclate in RAS.
STUDY DESIGN
A single-blinded placebo-controlled trial comprising 50 RAS subjects divided into group A and group B with 25 subjects in each group was performed. Patients in group A received topical application of crushed doxycycline hyclate tablet with denture adhesive and few drops of saline solution once at the initial visit. Group B received placebo similarly. Treatment response was assessed by measures of pain reduction, ulcer duration, and adhesive retention time. Data were analyzed using the Student t test.
RESULTS
Participants treated with doxycycline hyclate had significantly less pain by day 1 (P < .001) and healed faster (P < .001) compared with placebo.
CONCLUSION
A single application of doxycycline hyclate decreased pain and speeded recovery.
目的
尽管四环素类药物常用于复发性阿弗他口炎（RAS）患者的局部治疗，但很少有临床试验使用多西环素。因此，我们评估了盐酸多西环素局部治疗 RAS 的疗效。
研究设计
这是一项单盲安慰剂对照试验，纳入了 50 名 RAS 患者，分为 A 组和 B 组，每组 25 名患者。A 组患者在初次就诊时，将压碎的盐酸多西环素片与义齿胶粘剂和几滴生理盐水一起局部应用一次。B 组给予安慰剂治疗。通过疼痛减轻、溃疡持续时间和胶粘剂保留时间来评估治疗反应。使用学生 t 检验分析数据。
结果
与安慰剂相比，使用盐酸多西环素的患者在第 1 天疼痛明显减轻（P <.001），愈合更快（P <.001）。
结论
单次应用盐酸多西环素可减轻疼痛并加速恢复。
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