Zhang Feng, Zhou Hao, Ding Songyi, Zhang Da, Lian Daoshi, Chen Xingliang, Wang Chao
Acupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Sub-Health Center, Sichuan Integrative Medicine Hospital, Chengdu, China.
BMJ Open. 2020 Oct 7;10(10):e037603. doi: 10.1136/bmjopen-2020-037603.
Recurrent aphthous stomatitis (RAS) is a distressing symptom. There are many ways to treat RAS, such as pudilan anti-inflammatory oral liquid and doxycycline and laser therapy, but these take a long time to produce positive effects and compliance is low. Previous reviews of acupuncture treatment for RAS has been growing, but a systematic review is not available. To assess the efficacy and safety of acupuncture for the management of RAS.
The following databases will be searched from their inception to 1 February 2020: PubMed, Embase, Cochrane Library, CINAHL, Chinese Biomedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure and Wanfang. The randomised controlled trials in English or Chinese associated with acupuncture for patients with RAS will be included. Eligible study conference abstracts and reference lists of manuscripts will also be searched. Two reviewers will select the studies, extract data independently. The Cochrane risk of bias tool will be used to assess the risk of bias for the studies. According to heterogeneity testing, data will be synthesised using a random-effects model. A meta-analysis will be performed using Rev Man V.5.3.5 statistical software for each outcome. Subgroup analysis and sensitivity analysis are planned according to clinical evidence. Mean difference or standardised mean difference for continuous data and risk ratio for dichotomous data will be calculated.
No ethical approval is required. This protocol will not involve individual patient information and endangering participant rights. The results will be reported in a peer-reviewed journal or disseminated in relevant conferences.
DOI 10.17605/OSF.IO/QASUY.
复发性阿弗他口炎（RAS）是一种令人苦恼的症状。治疗RAS有多种方法，如蒲地蓝消炎口服液、强力霉素和激光治疗，但这些方法产生积极效果所需时间长且依从性低。以往关于针刺治疗RAS的综述不断增加，但尚无系统评价。目的是评估针刺治疗RAS的疗效和安全性。
将检索以下数据库自建库至2020年2月1日的数据：PubMed、Embase、Cochrane图书馆、CINAHL、中国生物医学文献数据库、中文科技期刊数据库（维普）、中国知网和万方。纳入与针刺治疗RAS患者相关的英文或中文随机对照试验。还将检索符合条件的研究会议摘要和手稿的参考文献列表。两名评价者将选择研究并独立提取数据。将使用Cochrane偏倚风险工具评估研究的偏倚风险。根据异质性检验，将采用随机效应模型合成数据。将使用Rev Man V.5.3.5统计软件对每个结局进行Meta分析。计划根据临床证据进行亚组分析和敏感性分析。将计算连续数据的平均差或标准化平均差以及二分数据的风险比。
无需伦理批准。本方案不涉及个体患者信息，也不会危及参与者权利。研究结果将在同行评审期刊上发表或在相关会议上传播。
DOI 10.17605/OSF.IO/QASUY。
